Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1-CETP)#Tall
• Allele Name: transgene insertion, Alan Tall
• Allele ID: MGI:4941577
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:4941578
cx2	Ldlr^tm1Her/Ldlr^tm1Her Tg(APOC3)3707Bres/? Tg(Mt1-CETP)#Tall/?	involves: 129S7/SvEvBrd * C57BL/6J * CBA/J	MGI:4941579

Genotype
MGI:4941578

cx1

• Allelic Composition: Apoa1^tm1Bres/Apoa1^tm1Bres; Tg(Mt1-CETP)#Tall/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 44% reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes

Genotype
MGI:4941579

cx2

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(APOC3)3707Bres/?; Tg(Mt1-CETP)#Tall/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:37861 )

• lowered by 79% on a normal diet

• lowered by 36% on a Western diet

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating LDL cholesterol level ( J:37861 )

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating VLDL cholesterol level ( J:37861 )

• cholesterol shifted from HDL to IDL-LDL and VLDL

increased circulating triglyceride level ( J:37861 )

• triglycerides shifted from VLDL to IDL-LDL and HDL