All Phenotypes Qpct<tm1.2Tbay> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Qpct^tm1.2Tbay
targeted mutation 1.2, Thomas A Bayer
MGI:4941596

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qpct^tm1.2Tbay/Qpct^tm1.2Tbay	B6.129S2-Qpct^tm1.2Tbay	MGI:4941717
cx2	Qpct^tm1.2Tbay/Qpct^tm1.2Tbay Tg(APPSwFlLon,PSEN1M146LL286V)6799Vas/0	B6.Cg-Qpct^tm1.2Tbay Tg(APPSwFlLon,PSEN1M146LL286V)6799Vas	MGI:4941718
cx3	Qpct^tm1.2Tbay/Qpct^tm1.2Tbay Trib2^{Tg(Thy1-Trh/APP)2.1Ingm}/Trib2^{Tg(Thy1-Trh/APP)2.1Ingm}	involves: 129S2/SvPas * C57BL/6J	MGI:5294364

Allelic Composition	Qpct^tm1.2Tbay/Qpct^tm1.2Tbay
Genetic Background	B6.129S2-Qpct^tm1.2Tbay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpct^tm1.2Tbay mutation (0 available); any Qpct mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:169481 )

N	• mice exhibit normal motor coordination and spatial working memory

Allelic Composition	Qpct^tm1.2Tbay/Qpct^tm1.2Tbay Tg(APPSwFlLon,PSEN1M146LL286V)6799Vas/0
Genetic Background	B6.Cg-Qpct^tm1.2Tbay Tg(APPSwFlLon,PSEN1M146LL286V)6799Vas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpct^tm1.2Tbay mutation (0 available); any Qpct mutation (8 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:169481 )

• at 6 months, mice exhibit a lower plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

behavior/neurological

behavior/neurological phenotype ( J:169481 )

N	• spatial working memory defects observed in Tg(APPSwFlLon,PSEN1M146LL286V)6799Vas mice are rescued • mice exhibit improved motor coordination on a beam or when suspended by a string compared with Tg(APPSwFlLon,PSEN1M146LL286V)6799Vas mice

homeostasis/metabolism

amyloid beta deposits ( J:169481 )

• at 6 months, mice exhibit a lower plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

Allelic Composition	Qpct^tm1.2Tbay/Qpct^tm1.2Tbay Trib2^{Tg(Thy1-Trh/APP)2.1Ingm}/Trib2^{Tg(Thy1-Trh/APP)2.1Ingm}
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpct^tm1.2Tbay mutation (0 available); any Qpct mutation (8 available)
Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm} mutation (0 available); any Trib2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:176575 )

• the pyroglutamate amyloid beta load is reduced compared to transgenic mice wild-type for Qpct

homeostasis/metabolism

amyloid beta deposits ( J:176575 )

• the pyroglutamate amyloid beta load is reduced compared to transgenic mice wild-type for Qpct

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