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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Madcam1tm1.2Nwag
targeted mutation 1.2, Norbert Wagner
MGI:4941725
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Madcam1tm1.2Nwag/Madcam1tm1.2Nwag B6.129P2-Madcam1tm1.2Nwag MGI:4941733


Genotype
MGI:4941733
hm1
Allelic
Composition		 Madcam1tm1.2Nwag/Madcam1tm1.2Nwag
Genetic
Background		 B6.129P2-Madcam1tm1.2Nwag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Madcam1tm1.2Nwag mutation (0 available); any Madcam1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased plasma cell number ( J:169739 )
• mice exhibit an increase in IgA-secreting plasma cells in the spleen and peripheral blood compared with wild-type mice
decreased B cell number ( J:169739 )
• in intestinal sections
decreased plasma cell number ( J:169739 )
• mice exhibit fewer IgA-secreting plasma cells in the lamina propria compared with wild-type mice
abnormal B cell physiology ( J:169739 )
• cholera-toxin-treated mice exhibit reduced homing of IgA-secreting plasma cells into the intestine compared with similarly treated wild-type mice
decreased IgA level ( J:169739 )
• in the small intestine prior to and following oral immunization with cholera toxin
small Peyer's patches ( J:169739 )
• at P3, mice exhibit an impairment of Peyer's patches compared with wild-type mice

hematopoietic system
increased plasma cell number ( J:169739 )
• mice exhibit an increase in IgA-secreting plasma cells in the spleen and peripheral blood compared with wild-type mice
decreased B cell number ( J:169739 )
• in intestinal sections
decreased plasma cell number ( J:169739 )
• mice exhibit fewer IgA-secreting plasma cells in the lamina propria compared with wild-type mice
abnormal B cell physiology ( J:169739 )
• cholera-toxin-treated mice exhibit reduced homing of IgA-secreting plasma cells into the intestine compared with similarly treated wild-type mice
decreased IgA level ( J:169739 )
• in the small intestine prior to and following oral immunization with cholera toxin




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory