Phenotypes associated with this allele

• Allele Symbol: Tbc1d4^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:4941737
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte	involves: C57BL/6	MGI:4941742
hm2	Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte	Not Specified	MGI:5437121

Genotype
MGI:4941742

hm1

• Allelic Composition: Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased testis weight ( J:169477 )

♂

homeostasis/metabolism

impaired glucose tolerance ( J:169477 )

insulin resistance ( J:169477 )

growth/size/body

increased heart weight ( J:169477 )

• in male mice

decreased body size ( J:169477 )

• slightly

muscle

decreased muscle cell glucose uptake ( J:169477 )

• lower upon insulin stimulation in vivo or ex vivo

increased muscle cell glucose uptake ( J:169477 )

• slightly higher under unstimulated conditions

adipose tissue

increased adipocyte glucose uptake ( J:169477 )

• higher upon insulin stimulation

cardiovascular system

increased heart weight ( J:169477 )

• in male mice

hematopoietic system

decreased spleen weight ( J:169477 )

• in female mice

endocrine/exocrine glands

increased testis weight ( J:169477 )

♂

immune system

decreased spleen weight ( J:169477 )

• in female mice

cellular

increased adipocyte glucose uptake ( J:169477 )

• higher upon insulin stimulation

decreased muscle cell glucose uptake ( J:169477 )

• lower upon insulin stimulation in vivo or ex vivo

increased muscle cell glucose uptake ( J:169477 )

• slightly higher under unstimulated conditions

Genotype
MGI:5437121

hm2

• Allelic Composition: Tbc1d4^tm1.1Arte/Tbc1d4^tm1.1Arte
• Genetic Background: Not Specified

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:186867 )

N • muscles exhibit normal contraction-induced glucose uptake

N • muscles exhibit normal AICAR-induced glucose uptake

N • whole body AICAR sensitivity is normal

muscle

muscle phenotype ( J:186867 )

N • muscles exhibit normal contraction-induced glucose uptake

N • muscles exhibit normal AICAR-induced glucose uptake