Analysis Tools
mortality/aging
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• mice do not survive beyond 3 weeks
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limbs/digits/tail
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• at E13.5 and E14.5, apoptosis cells in the mesenchyme between digits 2 and 3 and digits 3 and 4 is reduced with persistent webbing compared to in wild-type mice
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• at P14
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syndactyly
(
J:169180
)
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• soft tissue syndactyly at birth and P14
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• at E13.5 and E14.5, apoptosis cells in the mesenchyme between digits 2 and 3 and digits 3 and 4 is reduced with persistent webbing compared to in wild-type mice
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• the tibia/fibula and calcanea joint is malpositioned compared to in wild-type mice
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pes valgus
(
J:169180
)
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• mice exhibit pes valgus (foot bent outward at the talocalcanean joint) in the hind limb unlike wild-type mice
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short fibula
(
J:169180
)
bowed tibia
(
J:169180
)
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• mice exhibit stenosis between the fourth and fifth metatarsal unlike wild-type mice
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vision/eye
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• in some mice
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• at P0 and P14, optic diameter is reduced compared to in wild-type mice
|
|
• at E14.5, 11 of 12 eyes exhibit atrophy of the anteroventral part of the retina compared with wild-type mice
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• at E14.5, 10 of 12 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
• at P0, 3 of 6 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
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• at P0, all eyes exhibit retinal atrophy unlike wild-type mice
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growth/size/body
high palate
(
J:169180
)
|
• at P0 and P14
|
|
• at P0 and P14
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craniofacial
high palate
(
J:169180
)
skeleton
short fibula
(
J:169180
)
bowed tibia
(
J:169180
)
|
• mice exhibit stenosis between the fourth and fifth metatarsal unlike wild-type mice
|
|
• the tibia/fibula and calcanea joint is malpositioned compared to in wild-type mice
|
synostosis
(
J:169180
)
|
• mice exhibit stenosis between the fourth and fifth metatarsal unlike wild-type mice
|
nervous system
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• in some mice
|
|
• at P0 and P14, optic diameter is reduced compared to in wild-type mice
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pigmentation
|
• at E14.5, 10 of 12 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
• at P0, 3 of 6 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
|
digestive/alimentary system
high palate
(
J:169180
)
cellular
|
• at E13.5 and E14.5, apoptosis cells in the mesenchyme between digits 2 and 3 and digits 3 and 4 is reduced with persistent webbing compared to in wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| microphthalmia with limb anomalies | DOID:0060861 |
OMIM:206920 |
J:169180 | |
