Analysis Tools
mortality/aging
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• nearly all mice die between E11.5 and E13.5
• however, rare adult survivors are observed
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• nearly all mice die between E11.5 and E13.5
(J:169178)
• however, rare adult survivors are observed
(J:169178)
• more than 99% of mice die between E11.5 and E13.5 from failed erythropoiesis
(J:197237)
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hematopoietic system
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• mice die as a result from failed erythropoiesis
• however, primitive erythropoiesis and globin switching are normal
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• 2-fold in the fetal liver
• in rare surviving mice at 1 to 4 months
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• failed in most mice
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• rare surviving mice exhibit a strong block to conventional (B-2) pro- and pre-B cell development compared with wild-type mice
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• Rag2tm1Fwa Arid3atm1Pwt chimeras exhibit at 2- to 3-fold decrease in IgG1 class switching compared with control mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• decreased 2-fold in the fetal liver
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• in the fetal liver
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• in rare surviving mice at 1 to 4 months
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• hematopoietic stem cell differentiation is impaired compared to in wild-type mice
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• in rare surviving mice at 1 to 4 months
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• in unstimulated and TNP-KLH-treated rare surviving mice
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• in unstimulated and S. pneumoniae-immunized rare surviving mice
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embryo
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• at E12.5
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• mice die as a result from failed erythropoiesis
• however, primitive erythropoiesis and globin switching are normal
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growth/size/body
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• rare adult survivors
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cardiovascular system
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• at E12.5
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liver/biliary system
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• at E12.5
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integument
immune system
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• rare surviving mice exhibit a strong block to conventional (B-2) pro- and pre-B cell development compared with wild-type mice
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• Rag2tm1Fwa Arid3atm1Pwt chimeras exhibit at 2- to 3-fold decrease in IgG1 class switching compared with control mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice at 1 to 4 months
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in rare surviving mice
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• in unstimulated and TNP-KLH-treated rare surviving mice
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• in unstimulated and S. pneumoniae-immunized rare surviving mice
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cellular
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• cultured spleen, bone marrow, lymph nodes or kidney cells exhibit overgrowth and spontaneously form aggregates resembling multicellular, partially differentiated embryoid bodies that express pluripotency-associated markers unlike wild-type cells
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muscle
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• at E12.5
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