Phenotypes associated with this allele

• Allele Symbol: Tg(Aqp2-cre/ERT2)4Gsc
• Allele Name: transgene insertion 4, Gunther Schutz
• Allele ID: MGI:4941815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr3c2^tm2Gsc/Nr3c2^tm2Gsc Tg(Aqp2-cre/ERT2)4Gsc/0	involves: C57BL/6 * FVB/N	MGI:4941887

Genotype
MGI:4941887

cn1

• Allelic Composition: Nr3c2^tm2Gsc/Nr3c2^tm2Gsc; Tg(Aqp2-cre/ERT2)4Gsc/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:169670 )

N • tamoxifen-treated mice show no increase in food intake compared to controls, indicating that sodium intake is similar among all animals

increased circulating aldosterone level ( J:169670 )

• when 8 week-old mice received 1 mg of tamoxifen for 5 consecutive days, then were put on a standard diet and sacrificed 10 days later, plasma aldosterone levels were elevated compared to controls

increased urine sodium level ( J:169670 )

• tamoxifen-treated mice challenged with a low-sodium diet showed a significant increase in urinary sodium excretion

renal/urinary system

increased urine sodium level ( J:169670 )

• tamoxifen-treated mice challenged with a low-sodium diet showed a significant increase in urinary sodium excretion

polyuria ( J:169670 )

• tamoxifen-treated mice on a low-sodium diet show a significant increase in 24 hour urine volume compared to untreated mutants or treated controls; increase is greater than that measured for mutants expressing a constitutive Aqp2-cre transgene