All Phenotypes Sost<tm1Lhe> MGI Mouse

abnormal osteoblast physiology ( J:168665 )

• osteoblast activity were elevated in 17-week old mutant mice

decreased osteoblast apoptosis ( J:168665 )

• osteoblast apoptosis was impaired

decreased osteocyte apoptosis ( J:168665 )

• osteocyte apoptosis was significantly decreased

increased bone mineral density ( J:168665 )

• increase in total body BMD from as early as 4 wk and throughout life

increased bone mineral density of femur ( J:168665 )

• increase in femoral BMD from as early as 4 wk and throughout life

abnormal osteoblast morphology ( J:168665 )

• increased osteoblast surface by histmorphometric analysis

increased osteocyte number ( J:168665 )

• increased number of osteocytes, however there was no significant difference in osteocyte density

increased bone mass ( J:168665 )

• in 2 month old mice by radiographic analysis

• in both trabecular and cortical bone by muCT

• section of tibia at E14.5 and skeleton staining of P1 pups showed the bone development was normal section of tibia at E14.5 and skeleton staining of P1 pups showed the bone development was normal section of tibia at E14.5 and skeleton staining of P1 pups showed the bone development was normal

abnormal bone remodeling ( J:168665 )

• absence of unloading-induced decrease in BMD in 17-wk and 7-wk old mutant mice

• abrogation of unloading-induced reduction of cortical bone area and thickness