Phenotypes associated with this allele

• Allele Symbol: Usp7^tm1Wgu
• Allele Name: targeted mutation 1, Wei Gu
• Allele ID: MGI:4941831
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp7^tm1Wgu/Usp7^tm1Wgu	involves: 129 * C57BL/6J	MGI:4941832

Genotype
MGI:4941832

hm1

• Allelic Composition: Usp7^tm1Wgu/Usp7^tm1Wgu
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:168184 )

• dead embryo by E8.5 showing severely reduced cell mass and no advanced structures

• embryos died between E6.5 and E7.5

embryo

embryonic growth arrest ( J:168184 )

• at E7.5, markedly reduced number of BrdU label, but no increase in apoptosis

• blastocyst from E3.5 embryo failed to proliferate in vitro

decreased embryo size ( J:168184 )

• at E6.5, mutant embryos were smaller and had disorganized cells

absent proamniotic cavity ( J:168184 )

• at E6.5, no proamniotic cavity is formed

growth/size/body

decreased embryo size ( J:168184 )

• at E6.5, mutant embryos were smaller and had disorganized cells