Phenotypes associated with this allele

• Allele Symbol: P2ry6^tm1.1Brob
• Allele Name: targeted mutation 1.1, Bernard Robaye
• Allele ID: MGI:4941863
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P2ry6^tm1.1Brob/P2ry6^tm1.1Brob	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:4941868

Genotype
MGI:4941868

hm1

• Allelic Composition: P2ry6^tm1.1Brob/P2ry6^tm1.1Brob
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased vasoconstriction ( J:169742 )

• UTP- or UDP-treated aortic rings fail to exhibit an increase in contractile response unlike similarly treated wild-type aortic rings

decreased vasodilation ( J:169742 )

• UDP-treated aortic rings exhibit impaired relaxation compared with similarly treated wild-type aortic rings

immune system

abnormal macrophage physiology ( J:169742 )

• macrophages do not exhibit an increase in inositol phosphate production upon UDP or UTP treatment unlike wild-type cells

• macrophages treated with LPS and UDP fail to exhibit increased MIP-2 and IL6 secretion unlike similarly treated wild-type cells

• however, macrophages exhibit normal response to 100 uM ATP

muscle

decreased vasoconstriction ( J:169742 )

• UTP- or UDP-treated aortic rings fail to exhibit an increase in contractile response unlike similarly treated wild-type aortic rings

decreased vasodilation ( J:169742 )

• UDP-treated aortic rings exhibit impaired relaxation compared with similarly treated wild-type aortic rings

hematopoietic system

abnormal macrophage physiology ( J:169742 )

• macrophages do not exhibit an increase in inositol phosphate production upon UDP or UTP treatment unlike wild-type cells

• macrophages treated with LPS and UDP fail to exhibit increased MIP-2 and IL6 secretion unlike similarly treated wild-type cells

• however, macrophages exhibit normal response to 100 uM ATP