immune system
N |
• mice do not develop the same B and T cell abnormalities observed in Slatm1Weis homozygotes
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Allele Symbol Allele Name Allele ID |
Sla2tm1Amch targeted mutation 1, Alec M Cheng MGI:4941869 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice do not develop the same B and T cell abnormalities observed in Slatm1Weis homozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
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• bone marrow-derived dendritic cells treated with LPS and incubated with CD3-enriched cells elicit less T cell proliferation compared with similarly treated wild-type cells
• bone marrow-derived dendritic cells treated with LPS and pulsed with ovalbumin fail to induce increased production of IFN-gamma from Tg(DO11.10)10Dlo T cells compared with similarly treated wild-type cells
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• in bone marrow-derived dendritic cells grown in LPS, GM-CSF alone, or GM-CSF with IL4
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• in LPS-treated bone marrow-derived dendritic cells
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N |
• mice exhibit normal hematological parameters
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• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
|
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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