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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sla2tm1Amch
targeted mutation 1, Alec M Cheng
MGI:4941869
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sla2tm1Amch/Sla2tm1Amch involves: 129 MGI:4941874
cx2
 		Slatm1Weis/Slatm1Weis
Sla2tm1Amch/Sla2tm1Amch 		involves: 129 MGI:4941875


Genotype
MGI:4941874
hm1
Allelic
Composition		 Sla2tm1Amch/Sla2tm1Amch
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sla2tm1Amch mutation (1 available); any Sla2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:169170 )
N
• mice do not develop the same B and T cell abnormalities observed in Slatm1Weis homozygotes




Genotype
MGI:4941875
cx2
Allelic
Composition		 Slatm1Weis/Slatm1Weis
Sla2tm1Amch/Sla2tm1Amch
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sla2tm1Amch mutation (1 available); any Sla2 mutation (25 available)
Slatm1Weis mutation (1 available); any Sla mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell differentiation ( J:169170 )
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation
abnormal dendritic cell physiology ( J:169170 )
• bone marrow-derived dendritic cells treated with LPS and incubated with CD3-enriched cells elicit less T cell proliferation compared with similarly treated wild-type cells
• bone marrow-derived dendritic cells treated with LPS and pulsed with ovalbumin fail to induce increased production of IFN-gamma from Tg(DO11.10)10Dlo T cells compared with similarly treated wild-type cells
decreased interleukin-12 secretion ( J:169170 )
• in bone marrow-derived dendritic cells grown in LPS, GM-CSF alone, or GM-CSF with IL4
decreased tumor necrosis factor secretion ( J:169170 )
• in LPS-treated bone marrow-derived dendritic cells

hematopoietic system
hematopoietic system phenotype ( J:169170 )
N
• mice exhibit normal hematological parameters
abnormal dendritic cell differentiation ( J:169170 )
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation

cellular
abnormal dendritic cell differentiation ( J:169170 )
• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells
• however, LPS treatment partially rescues maturation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory