Phenotypes associated with this allele

• Allele Symbol: Selenok^tm1.2Itl
• Allele Name: targeted mutation 1.2, inGenious Targeting Laboratory
• Allele ID: MGI:4941878
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenok^tm1.2Itl/Selenok^tm1.2Itl	involves: BALB/cJ * C57BL/6	MGI:4941882

Genotype
MGI:4941882

hm1

• Allelic Composition: Selenok^tm1.2Itl/Selenok^tm1.2Itl
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:169169 )

• West Nile virus (WNV)-infected mice exhibit increased lethality compared with similarly treated wild-type mice

immune system

abnormal neutrophil physiology ( J:169169 )

• neutrophils exhibit decreased receptor-mediated calcium flux compared with wild-type cells

impaired neutrophil chemotaxis ( J:169169 )

• in response to KC treatment and in a model of peritonitis

abnormal T cell physiology ( J:169169 )

• T cells exhibit decreased receptor-mediated calcium flux compared with wild-type cells

• SDF-1 and RANTES-treated T cells exhibit decreased migration compared with wild-type cells

decreased T cell proliferation ( J:169169 )

abnormal macrophage physiology ( J:169169 )

• macrophages exhibit decreased receptor-mediated calcium flux compared with wild-type cells

• macrophages exhibit reduced Fcgamma receptor-mediated oxidative bursts compared with wild-type cells

abnormal circulating chemokine level ( J:169169 )

• mice exhibit decreased serum levels of KC and MCP1 compared with wild-type mice

decreased interleukin-6 secretion ( J:169169 )

• from bone marrow-derived macrophage treated with LPS and pIpC

decreased tumor necrosis factor secretion ( J:169169 )

• from bone marrow-derived macrophage treated with LPS and pIpC

increased susceptibility to Flaviviridae infection ( J:169169 )

• West Nile virus (WNV)-infected mice exhibit increased lethality, increased neuronal degeneration, inadequate viral clearance, decreased serum MCP1 and IL6 levels, and increased brain MCP1 level compared with similarly treated wild-type mice

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:169169 )

• West Nile virus (WNV)-infected mice exhibit increased lethality compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal circulating chemokine level ( J:169169 )

• mice exhibit decreased serum levels of KC and MCP1 compared with wild-type mice

hematopoietic system

abnormal neutrophil physiology ( J:169169 )

• neutrophils exhibit decreased receptor-mediated calcium flux compared with wild-type cells

impaired neutrophil chemotaxis ( J:169169 )

• in response to KC treatment and in a model of peritonitis

abnormal T cell physiology ( J:169169 )

• T cells exhibit decreased receptor-mediated calcium flux compared with wild-type cells

• SDF-1 and RANTES-treated T cells exhibit decreased migration compared with wild-type cells

decreased T cell proliferation ( J:169169 )

abnormal macrophage physiology ( J:169169 )

• macrophages exhibit decreased receptor-mediated calcium flux compared with wild-type cells

• macrophages exhibit reduced Fcgamma receptor-mediated oxidative bursts compared with wild-type cells

cellular

impaired neutrophil chemotaxis ( J:169169 )

• in response to KC treatment and in a model of peritonitis

decreased T cell proliferation ( J:169169 )