All Phenotypes Adora2b<tm1Msit> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adora2b^tm1Msit
targeted mutation 1, Michail Sitkovsky
MGI:4941885

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adora2b^tm1Msit/Adora2b^tm1Msit Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4941888
cn2	Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Sftpc-cre)1Blh/0	involves: C57BL/6 * DBA/2	MGI:6151087
cn3	Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Cdh5-cre)7Mlia/0	involves: FVB/N	MGI:6151086

Allelic Composition	Adora2b^tm1Msit/Adora2b^tm1Msit Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2b^tm1Msit mutation (0 available); any Adora2b mutation (20 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:169155 )

• following cecal ligation and puncture, mice exhibit increased bacterial clearance compared with wild-type mice

Allelic Composition	Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2b^tm1Msit mutation (0 available); any Adora2b mutation (20 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to injury ( J:203572 )

• following acute lung injury, dipyridamole-treated mice exhibit increased PMN trafficking and fail to exhibit a decrease in lung IL6 compared with wild-type mice

Allelic Composition	Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Cdh5-cre)7Mlia/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2b^tm1Msit mutation (0 available); any Adora2b mutation (20 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203572 )

N	• following acute lung injury, dipyridamole-treated mice exhibit normal PMN trafficking

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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