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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adora2btm1.1Msit
targeted mutation 1.1, Michail Sitkovsky
MGI:4941886
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adora2btm1.1Msit/Adora2btm1.1Msit either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR) MGI:4941889
hm2
 		Adora2btm1.1Msit/Adora2btm1.1Msit involves: BALB/cJ MGI:6151085


Genotype
MGI:4941889
hm1
Allelic
Composition		 Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic
Background		 either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2btm1.1Msit mutation (0 available); any Adora2b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:169155 )
• mice subjected to cecal ligation and puncture exhibit less lethality compared with similarly treated wild-type mice

immune system
abnormal macrophage physiology ( J:169155 )
• following cecal ligation and puncture, mice exhibit enhanced macrophage-mediated microbicidal activity compared with similarly treated wild-type mice
increased interleukin-6 secretion ( J:169155 )
• in LPS-stimulated of septic macrophage
increased tumor necrosis factor secretion ( J:169155 )
• in LPS-stimulated of septic macrophage

cardiovascular system
increased heart rate ( J:169155 )
• following cecal ligation and puncture
increased mean systemic arterial blood pressure ( J:169155 )
• following cecal ligation and puncture
increased systemic arterial systolic blood pressure ( J:169155 )
• following cecal ligation and puncture

homeostasis/metabolism
decreased susceptibility to injury ( J:169155 )
• mice subjected to cecal ligation and puncture exhibit less lethality, improved cardiovascular function, increased fluid retention, increased bacteria clearance, and enhanced macrophage-mediated microbicidal activity compared with similarly treated wild-type mice

hematopoietic system
abnormal macrophage physiology ( J:169155 )
• following cecal ligation and puncture, mice exhibit enhanced macrophage-mediated microbicidal activity compared with similarly treated wild-type mice




Genotype
MGI:6151085
hm2
Allelic
Composition		 Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2btm1.1Msit mutation (0 available); any Adora2b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:203572 )
• following acute lung injury, dipyridamole-treated mice exhibit increased PMN trafficking compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory