About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1Hbu
targeted mutation 1, Hansruedi Bueler
MGI:4941901
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1Hbu/Pink1tm1Hbu involves: 129S7/SvEvBrd * C57BL/6 MGI:4941907


Genotype
MGI:4941907
hm1
Allelic
Composition
Pink1tm1Hbu/Pink1tm1Hbu
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Hbu mutation (0 available); any Pink1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the striatum of LPS-treated mice
• in the striatum of LPS-treated mice
• in the striatum of LPS-treated mice

cellular
• brain mitochondria exhibit reduced threshold for calcium-induced permeability transition pore opening compared with wild-type mitochondria

homeostasis/metabolism
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 6 DOID:0060369 OMIM:605909
J:169471





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory