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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prickle2tm1Nue
targeted mutation 1, Naoto Ueno
MGI:4941925
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prickle2tm1Nue/Prickle2tm1Nue B6.Cg-Prickle2tm1Nue MGI:4941931
ht2
 		Prickle2tm1Nue/Prickle2+ B6.Cg-Prickle2tm1Nue MGI:4941930


Genotype
MGI:4941931
hm1
Allelic
Composition		 Prickle2tm1Nue/Prickle2tm1Nue
Genetic
Background		 B6.Cg-Prickle2tm1Nue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle2tm1Nue mutation (1 available); any Prickle2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:169136 )
• pentylenetetrazole-treated mice exhibit increased epileptiform discharges compared with similarly treated wild-type mice
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice
• seizure rates are higher than in heterozygotes

nervous system
increased susceptibility to pharmacologically induced seizures ( J:169136 )
• pentylenetetrazole-treated mice exhibit increased epileptiform discharges compared with similarly treated wild-type mice
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice
• seizure rates are higher than in heterozygotes




Genotype
MGI:4941930
ht2
Allelic
Composition		 Prickle2tm1Nue/Prickle2+
Genetic
Background		 B6.Cg-Prickle2tm1Nue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle2tm1Nue mutation (1 available); any Prickle2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice

nervous system
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory