About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prickle2tm1Nue
targeted mutation 1, Naoto Ueno
MGI:4941925
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prickle2tm1Nue/Prickle2tm1Nue B6.Cg-Prickle2tm1Nue MGI:4941931
ht2
 		Prickle2tm1Nue/Prickle2+ B6.Cg-Prickle2tm1Nue MGI:4941930


Genotype
MGI:4941931
hm1
Allelic
Composition		 Prickle2tm1Nue/Prickle2tm1Nue
Genetic
Background		 B6.Cg-Prickle2tm1Nue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle2tm1Nue mutation (1 available); any Prickle2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:169136 )
• pentylenetetrazole-treated mice exhibit increased epileptiform discharges compared with similarly treated wild-type mice
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice
• seizure rates are higher than in heterozygotes

nervous system
increased susceptibility to pharmacologically induced seizures ( J:169136 )
• pentylenetetrazole-treated mice exhibit increased epileptiform discharges compared with similarly treated wild-type mice
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice
• seizure rates are higher than in heterozygotes




Genotype
MGI:4941930
ht2
Allelic
Composition		 Prickle2tm1Nue/Prickle2+
Genetic
Background		 B6.Cg-Prickle2tm1Nue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle2tm1Nue mutation (1 available); any Prickle2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice

nervous system
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory