Analysis Tools
mortality/aging
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• no live born mice were produced
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craniofacial
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• at E11.5, the maxilla processes are smaller than in wild-type controls
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• at E13.5, cell proliferation is significantly reduced in the posterior palate but not in the anterior palate
• however, TUNEL analysis showed no obvious changes in apoptosis at E13.5
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• at E11.5, the anterior palate is already shorter than the wild-type palate; shortened palate is further affected by delayed Shh upregulation or rugae formation
• at E13.5, cell proliferation is significantly reduced in the posterior palate but not in the anterior palate
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• at E18.5, the right palatal shelf is often more deformed, curved and farther away from the midline compared to the left shelf
• at E11.5, palatal shelves are shorter and curved differently; in the anterior palate, the Shh-positive region is already ~30% shorter than in wild-type controls
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• in some E18.5 mice, the two palate shelves fail to rise to the horizontal position
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• in some E18.5 mice, the two palate shelves have risen to the horizontal position above the tongue but are too short to contact or fuse at the midline
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• at E12.5 to E15, the length of the palatal shelves is about 80.3 +/- 2.83% of that in wild-type controls
• at E11.5, palatal shelves are shorter due to shorter maxilla processes at the onset of palate development
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• at E12.5, E13 and E13.5, Shh expression showed one less palatal ruga than in the wild-type palate at each stage
• by E15.5, the number of palatal rugae is normal, indicating that rugae development is delayed; however, the medial edges of the palate shelves do not develop rugae in the anterior palate
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• at E18.5, the secondary palate is completely open
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short snout
(
J:223183
)
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• at E18.5, the snout is ~10% shorter than in wild-type controls, as defined by the distance from the snout tip to the center of the eyes
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growth/size/body
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• at E11.5, the maxilla processes are smaller than in wild-type controls
|
|
• at E13.5, cell proliferation is significantly reduced in the posterior palate but not in the anterior palate
• however, TUNEL analysis showed no obvious changes in apoptosis at E13.5
|
|
• at E11.5, the anterior palate is already shorter than the wild-type palate; shortened palate is further affected by delayed Shh upregulation or rugae formation
• at E13.5, cell proliferation is significantly reduced in the posterior palate but not in the anterior palate
|
|
• at E18.5, the right palatal shelf is often more deformed, curved and farther away from the midline compared to the left shelf
• at E11.5, palatal shelves are shorter and curved differently; in the anterior palate, the Shh-positive region is already ~30% shorter than in wild-type controls
|
|
• in some E18.5 mice, the two palate shelves fail to rise to the horizontal position
|
|
• in some E18.5 mice, the two palate shelves have risen to the horizontal position above the tongue but are too short to contact or fuse at the midline
|
|
• at E12.5 to E15, the length of the palatal shelves is about 80.3 +/- 2.83% of that in wild-type controls
• at E11.5, palatal shelves are shorter due to shorter maxilla processes at the onset of palate development
|
|
• at E12.5, E13 and E13.5, Shh expression showed one less palatal ruga than in the wild-type palate at each stage
• by E15.5, the number of palatal rugae is normal, indicating that rugae development is delayed; however, the medial edges of the palate shelves do not develop rugae in the anterior palate
|
|
• at E18.5, the secondary palate is completely open
|
short snout
(
J:223183
)
|
• at E18.5, the snout is ~10% shorter than in wild-type controls, as defined by the distance from the snout tip to the center of the eyes
|
digestive/alimentary system
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• at E11.5, the maxilla processes are smaller than in wild-type controls
|
|
• at E13.5, cell proliferation is significantly reduced in the posterior palate but not in the anterior palate
• however, TUNEL analysis showed no obvious changes in apoptosis at E13.5
|
|
• at E11.5, the anterior palate is already shorter than the wild-type palate; shortened palate is further affected by delayed Shh upregulation or rugae formation
• at E13.5, cell proliferation is significantly reduced in the posterior palate but not in the anterior palate
|
|
• at E18.5, the right palatal shelf is often more deformed, curved and farther away from the midline compared to the left shelf
• at E11.5, palatal shelves are shorter and curved differently; in the anterior palate, the Shh-positive region is already ~30% shorter than in wild-type controls
|
|
• in some E18.5 mice, the two palate shelves fail to rise to the horizontal position
|
|
• in some E18.5 mice, the two palate shelves have risen to the horizontal position above the tongue but are too short to contact or fuse at the midline
|
|
• at E12.5 to E15, the length of the palatal shelves is about 80.3 +/- 2.83% of that in wild-type controls
• at E11.5, palatal shelves are shorter due to shorter maxilla processes at the onset of palate development
|
|
• at E12.5, E13 and E13.5, Shh expression showed one less palatal ruga than in the wild-type palate at each stage
• by E15.5, the number of palatal rugae is normal, indicating that rugae development is delayed; however, the medial edges of the palate shelves do not develop rugae in the anterior palate
|
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• at E18.5, the secondary palate is completely open
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skeleton
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• at E11.5, the maxilla processes are smaller than in wild-type controls
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