All Phenotypes Nkx2-1<tm3Rdl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx2-1^tm3Rdl
targeted mutation 3, Roberto Di Lauro
MGI:4941952

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx2-1^tm3Rdl/Nkx2-1^tm3Rdl	B6.129-Nkx2-1^tm3Rdl	MGI:4941962

Allelic Composition	Nkx2-1^tm3Rdl/Nkx2-1^tm3Rdl
Genetic Background	B6.129-Nkx2-1^tm3Rdl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-1^tm3Rdl mutation (0 available); any Nkx2-1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• presumably from respiratory failure

endocrine/exocrine glands

• at E11.5, only a thyroid bud is observed unlike in a wild-type mice

absent thyroid gland ( J:169693 )

• at E16.5

respiratory system

abnormal lung morphology ( J:169693 )

respiratory failure ( J:169693 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24