All Phenotypes Nkx2-1<tm3Rdl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx2-1^tm3Rdl
targeted mutation 3, Roberto Di Lauro
MGI:4941952

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx2-1^tm3Rdl/Nkx2-1^tm3Rdl	B6.129-Nkx2-1^tm3Rdl	MGI:4941962

Allelic Composition	Nkx2-1^tm3Rdl/Nkx2-1^tm3Rdl
Genetic Background	B6.129-Nkx2-1^tm3Rdl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-1^tm3Rdl mutation (0 available); any Nkx2-1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• presumably from respiratory failure

endocrine/exocrine glands

• at E11.5, only a thyroid bud is observed unlike in a wild-type mice

absent thyroid gland ( J:169693 )

• at E16.5

respiratory system

abnormal lung morphology ( J:169693 )

respiratory failure ( J:169693 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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