Phenotypes associated with this allele

• Allele Symbol: Tg(Trpv1-cre)1Hoon
• Allele Name: transgene insertion 1, Mark A Hoon
• Allele ID: MGI:4942415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor^+ Tg(Trpv1-cre)1Hoon/0	involves: 129S1/Sv	MGI:5013957

Genotype
MGI:5013957

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Tg(Trpv1-cre)1Hoon/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:169256 )

N • animals do not exhibit any signs of self-mutilation or taste response deficits

N • animals have normal mechanosensory responses following nerve ligation or sensitization by inflammation; responses in assays for touch and pinch assays are identical to controls

N • rotarod results are normal, indicating no loss of proprioceptive function

abnormal chemical nociception ( J:169256 )

• responses to capsaicin and mustard oil in eye wipe and paw injection paradigms are eliminated

• animals display no 'wet-dog shakes' in response to icilin injection which gives perception of cooling, whereas controls show robust characteristic responses

increased thermal nociceptive threshold ( J:169256 )

• mice are insensitive to noxious heat compared to controls (animals do not display protective thermosensory responses in hot plate paw withdrawal or tail-flick assays)

• mice show no reaction to a cold plate assay or preference in a 2-temperature choice test (30 C vs 5 C)

nervous system

nervous system phenotype ( J:169256 )

N • distribution and arrangement of dorsal horn interneurons is not significantly different from wild-type animals

N • recordings from sciatic nerve in response to stimulation of the foot (by brush, von Frey microfilaments, or vibration) are not different than in controls

N • rotarod results are normal, indicating no loss of proprioceptive function

decreased sensory neuron number ( J:169256 )

• mutants have reduced numbers of TRPV2-containing sensory neurons

homeostasis/metabolism

abnormal body temperature homeostasis ( J:169256 )

• in response to IP injection of capsaicin, mice do not exhibit the profound hypothermia that is shown by treated controls

• mutants are unable to maintain their body temperature than wild-type controls when the environmental temperature is changed

• animals exhibit a greater hypothermic response than wild-type upon antigen injection, with slower re-establishment of normal resting temperature

• animals show a greater temperature change in response to mild fever induced by Il-1beta injection relative to wild-type

immune system

decreased inflammatory response ( J:169256 )

• responses to ATP, prostaglandins, bradykinin, histamine and serotonin are lost in mutants; significant loss of neurogenic inflammation is observed, and significantly less inflammation occurs in response to carageenan challenge

integument

decreased pruritus ( J:169256 )

• mutants display complete loss of behavioral responses to injection of pruritogenic compounds