cellular
• anti-Fas antibody fails to induce cell death in T-cells as it does in controls
• resistant to FasL induced cell death
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immune system
N |
• thymus, spleen, and lymph nodes all appear to be normal
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• peripheral B-cells are increased in number
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• TCR activation of T-cells is reduced
|
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice
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hematopoietic system
• peripheral B-cells are increased in number
|
• TCR activation of T-cells is reduced
|
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice
|