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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Fadd/EGFP)#Jizh
transgene insertion, Jianke Zhang
MGI:4943162
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Lck-cre)1Cwi/?
involves: 129S4/SvJae MGI:4943254
cn2
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJae * C57BL/6 * CBA MGI:4943260
cn3
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Cd4-cre)1Cwi/?
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:4943257


Genotype
MGI:4943254
cn1
Allelic
Composition
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Lck-cre)1Cwi/?
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Wnt mutation (0 available); any Fadd mutation (18 available)
Tg(Fadd/EGFP)#Jizh mutation (0 available)
Tg(Lck-cre)1Cwi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• anti-Fas antibody fails to induce cell death in T-cells as it does in controls
• resistant to FasL induced cell death

immune system
N
• thymus, spleen, and lymph nodes all appear to be normal
• peripheral B-cells are increased in number
• TCR activation of T-cells is reduced
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice

hematopoietic system
• peripheral B-cells are increased in number
• TCR activation of T-cells is reduced
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice




Genotype
MGI:4943260
cn2
Allelic
Composition
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Wnt mutation (0 available); any Fadd mutation (18 available)
Tg(Fadd/EGFP)#Jizh mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cellularity is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
• bone marrow progenitor cells with a decreased tendency to develop into macrophage and dendritic cells after induction with poly(I:C)
• progenitors have reduced in vitro colony forming ability
• cellularity of bone marrow is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
• RBC volume in peripheral blood is significantly reduced up to 6 days after induction with poly(I:C)
• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly
• cell numbers continue to drop over a 3 month period

immune system
• cellularity is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly
• cell numbers continue to drop over a 3 month period

endocrine/exocrine glands
• cellularity is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period




Genotype
MGI:4943257
cn3
Allelic
Composition
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Cd4-cre)1Cwi/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Wnt mutation (0 available); any Fadd mutation (18 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(Fadd/EGFP)#Jizh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• anti-Fas antibody fails to induce cell death in T-cells as it does in controls
• resistant to FasL induced cell death

immune system
N
• thymus, spleen, and lymph nodes all appear to be normal
• peripheral B-cells are increased in number
• TCR activation of T-cells is reduced
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice

hematopoietic system
• peripheral B-cells are increased in number
• TCR activation of T-cells is reduced
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory