Phenotypes associated with this allele

• Allele Symbol: Zic2^m1Nisw
• Allele Name: mutation 1, Lee Niswander
• Allele ID: MGI:4943187
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zic2^m1Nisw/Zic2^m1Nisw	129S1.B6-Zic2^m1Nisw	MGI:4943230

Genotype
MGI:4943230

hm1

• Allelic Composition: Zic2^m1Nisw/Zic2^m1Nisw
• Genetic Background: 129S1.B6-Zic2^m1Nisw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:214510 )

• embryos do not survive beyond birth due to neural tube defects

nervous system

abnormal enteric neural crest cell morphology ( J:214510 )

• reduced distance between the neurite bundles connecting enteric ganglia (internodal strands) in both the E18.5 myenteric plexus and the inner submucosal plexus, although length of the gut is not affected

• extensive outgrowth of neurites in E13.5 midgut as compared to wild-type

spina bifida ( J:214510 )

• 100% incidence of spina bifida

abnormal enteric nervous system morphology ( J:214510 )

• enteric nervous system dysplasia

abnormal enteric neuron morphology ( J:214510 )

• increase in the number of enteric neurons

exencephaly ( J:169832 , J:214510 )

• mice exhibit exencephaly of the hind-, mid-, and forebrain unlike wild-type mice (J:169832)

• 30% incidence of exencephaly (J:214510)

abnormal neurite morphology ( J:214510 )

• extensive outgrowth of neurites in E13.5 midgut as compared to wild-type

digestive/alimentary system

abnormal intestine morphology ( J:214510 )

• green and/or dark red intestines observed in E18.5 embryos as compared to yellow color found in wild-type

abnormal intestine physiology ( J:214510 )

• abnormal accumulation of material (meconium) in the intestines of E18.5 embryos

embryo

abnormal enteric neural crest cell morphology ( J:214510 )

• reduced distance between the neurite bundles connecting enteric ganglia (internodal strands) in both the E18.5 myenteric plexus and the inner submucosal plexus, although length of the gut is not affected

• extensive outgrowth of neurites in E13.5 midgut as compared to wild-type

spina bifida ( J:214510 )

• 100% incidence of spina bifida