Phenotypes associated with this allele

• Allele Symbol: Pcsk9^tm1.2Prat
• Allele Name: targeted mutation 1.2, Annik Prat
• Allele ID: MGI:4943496
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat	involves: 129S1/Sv * 129X1/SvJ	MGI:4943541
cx2	Ldlr^tm1Her/Ldlr^tm1Her Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:4943544

Genotype
MGI:4943541

hm1

• Allelic Composition: Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:169834 )

• cholesterol synthesis is up regulated after partial hepatectomy by about 2.5 fold

decreased circulating cholesterol level ( J:169834 )

• total plasma cholesterol reduced 42%

decreased circulating HDL cholesterol level ( J:169834 )

• plasma levels are 62% of levels in controls

decreased circulating LDL cholesterol level ( J:169834 )

• plasma levels are 20% of levels in controls

liver/biliary system

abnormal liver regeneration ( J:169834 )

• necrotic foci found in the periphery of liver lobes remaining after partial hepatectomy

• liver architecture disrupted in the periphery of liver lobes remaining after partial hepatectomy

• high cholesterol diet results in slightly improved regeneration and no necrotic lesions

impaired liver regeneration ( J:169834 )

• liver regeneration is slower than in controls

• full liver mass is not recovered until 14 days after surgery

Genotype
MGI:4943544

cx2

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:169834 )

• plasma levels are increased 14.8 fold relative to controls

• plasma HDL levels are unaffected