About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TSPY1-Figla)#Dean
transgene insertion, Jurrien Dean
MGI:4943525
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(TSPY1-Figla)#Dean/? FVB/N-Tg(TSPY1-Figla)#Dean MGI:5008263


Genotype
MGI:5008263
tg1
Allelic
Composition
Tg(TSPY1-Figla)#Dean/?
Genetic
Background
FVB/N-Tg(TSPY1-Figla)#Dean
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TSPY1-Figla)#Dean mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• tubules become increasingly vacuolar
• by 7 months of age vacuolation is widespread and half of the tubules exhibit signs of degeneration
• by 7 weeks of age testes are 27% smaller than controls

reproductive system
• 50% of sperm have severe tail angulation
• germ cells exhibit loss of chromatoid body integrity
• by 7-8 weeks seminiferous tubules contain abnormally large spermatocytes
• by 3 weeks of age seminiferous tubules contain fewer germ cells than controls
• apoptotic germ cells are detected beginning at 4 months of age and become abundant by 5 months of age
• 20% fewer sperm are recovered from 5 month old males than controls
• meiotic progression is delayed or arrested in prophase I
• by 5 months of age, multiple germ cells with tubules do not complete meiosis
• sperm exhibits decreased motility, progressive motion and hyperactivity
• tubules become increasingly vacuolar
• by 7 months of age vacuolation is widespread and half of the tubules exhibit signs of degeneration
• by 7 weeks of age testes are 27% smaller than controls
• all males become infertile by 5 months of age although some become infertile as early as 3 months
• in-vitro fertilization (IVF) success rates decrease with the use of sperm from 2 month old males
• sperm from 5 month old males binds to ovulated eggs at much lower numbers than controls

cellular
• 50% of sperm have severe tail angulation
• germ cells exhibit loss of chromatoid body integrity
• by 7-8 weeks seminiferous tubules contain abnormally large spermatocytes
• by 3 weeks of age seminiferous tubules contain fewer germ cells than controls
• apoptotic germ cells are detected beginning at 4 months of age and become abundant by 5 months of age
• 20% fewer sperm are recovered from 5 month old males than controls
• by 5 months of age, multiple germ cells with tubules do not complete meiosis
• meiotic progression is delayed or arrested in prophase I
• sperm exhibits decreased motility, progressive motion and hyperactivity





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory