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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TSPY1-Figla)#Dean
transgene insertion, Jurrien Dean
MGI:4943525
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(TSPY1-Figla)#Dean/? FVB/N-Tg(TSPY1-Figla)#Dean MGI:5008263


Genotype
MGI:5008263
tg1
Allelic
Composition
Tg(TSPY1-Figla)#Dean/?
Genetic
Background
FVB/N-Tg(TSPY1-Figla)#Dean
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TSPY1-Figla)#Dean mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• tubules become increasingly vacuolar
• by 7 months of age vacuolation is widespread and half of the tubules exhibit signs of degeneration
• by 7 weeks of age testes are 27% smaller than controls

reproductive system
• 50% of sperm have severe tail angulation
• germ cells exhibit loss of chromatoid body integrity
• by 7-8 weeks seminiferous tubules contain abnormally large spermatocytes
• by 3 weeks of age seminiferous tubules contain fewer germ cells than controls
• apoptotic germ cells are detected beginning at 4 months of age and become abundant by 5 months of age
• 20% fewer sperm are recovered from 5 month old males than controls
• by 5 months of age, multiple germ cells with tubules do not complete meiosis
• meiotic progression is delayed or arrested in prophase I
• sperm exhibits decreased motility, progressive motion and hyperactivity
• tubules become increasingly vacuolar
• by 7 months of age vacuolation is widespread and half of the tubules exhibit signs of degeneration
• by 7 weeks of age testes are 27% smaller than controls
• all males become infertile by 5 months of age although some become infertile as early as 3 months
• in-vitro fertilization (IVF) success rates decrease with the use of sperm from 2 month old males
• sperm from 5 month old males binds to ovulated eggs at much lower numbers than controls

cellular
• 50% of sperm have severe tail angulation
• germ cells exhibit loss of chromatoid body integrity
• by 7-8 weeks seminiferous tubules contain abnormally large spermatocytes
• by 3 weeks of age seminiferous tubules contain fewer germ cells than controls
• apoptotic germ cells are detected beginning at 4 months of age and become abundant by 5 months of age
• 20% fewer sperm are recovered from 5 month old males than controls
• by 5 months of age, multiple germ cells with tubules do not complete meiosis
• meiotic progression is delayed or arrested in prophase I
• sperm exhibits decreased motility, progressive motion and hyperactivity





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory