Phenotypes associated with this allele

• Allele Symbol: Tdrd7^nmf166
• Allele Name: neuroscience mutagenesis facility, 166
• Allele ID: MGI:4943539
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tdrd7^nmf166/Tdrd7^nmf166	B6;129-Tdrd7^nmf166/J	MGI:3041630
hm2	Tdrd7^nmf166/Tdrd7^nmf166	involves: C3H * C57BL/6J	MGI:4943549

Genotype
MGI:3041630

hm1

• Allelic Composition: Tdrd7^nmf166/Tdrd7^nmf166
• Genetic Background: B6;129-Tdrd7^nmf166/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased eye anterior chamber depth ( J:87349 )

• eye examination at 12 weeks of age revealed deep anterior chambers

cataract ( J:87349 )

• eye examination at 12 weeks of age revealed lens extrusion cataracts

Genotype
MGI:4943549

hm2

• Allelic Composition: Tdrd7^nmf166/Tdrd7^nmf166
• Genetic Background: involves: C3H * C57BL/6J

vision/eye

uveitis ( J:169836 )

• posterior uveitis in 2 mice at 0ver 24 months of age

optic neuropathy ( J:169836 )

• severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen

abnormal iris morphology ( J:169836 )

• iris flattening is detected by 4 months of age

increased eye anterior chamber depth ( J:169836 )

• increased depth is seen by 4 months of age

abnormal lens morphology ( J:169836 )

• lens extrusion at later stages

• in some cases the mass of fiber cells pass through the pupil into the anterior chamber of the eye

ruptured lens capsule ( J:169836 )

• rupture and extrusion of fiber cell mass into the vitreous at later stages

abnormal lens fiber morphology ( J:169836 )

• develop vacuoles at later stages

cataract ( J:169836 )

• all develop posterior cataracts by 4 weeks of age that become more severe with age

ocular hypertension ( J:169836 )

• detected in some mice by 6 months of age

• incidence increases with age

reproductive system

arrest of spermatogenesis ( J:169836 )

♂ • arrests at the round spermatid stage

male infertility ( J:169836 )

♂

nervous system

optic neuropathy ( J:169836 )

• severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen

immune system

uveitis ( J:169836 )

• posterior uveitis in 2 mice at 0ver 24 months of age