Phenotypes associated with this allele

• Allele Symbol: Ttn^tm2.1Mgot
• Allele Name: targeted mutation 2.1, Michael Gotthardt
• Allele ID: MGI:4946083
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttn^tm2.1Mgot/Ttn^tm2.1Mgot	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:4946085
ht2	Ttn^tm2.1Mgot/Ttn^+	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:4946086

Genotype
MGI:4946085

hm1

• Allelic Composition: Ttn^tm2.1Mgot/Ttn^tm2.1Mgot
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:169969 )

• increased cell length

cardiac hypertrophy ( J:169969 )

increased heart left ventricle size ( J:169969 )

• diastolic and systolic left ventricular volumes are increased compared to in wild-type mice

heart left ventricle hypertrophy ( J:169969 )

increased heart left ventricle weight ( J:169969 )

abnormal cardiac muscle contractility ( J:169969 )

• left ventricle stiffness and diastolic dysfunction is indicated by reduced deceleration time and increased late filling velocity compared to in wild-type mice

muscle

increased myocardial fiber size ( J:169969 )

• increased cell length

heart left ventricle hypertrophy ( J:169969 )

abnormal sarcomere morphology ( J:169969 )

• total passive tension sarcomere length in cardiac left ventricular muscle is increased compared to in wild-type mice

• however, mice exhibit normal slack gross sarcomere morphology, length and maximal active tension

abnormal muscle physiology ( J:169969 )

• mice exhibit increased diastolic wall stress compared with wild-type mice

abnormal cardiac muscle contractility ( J:169969 )

• left ventricle stiffness and diastolic dysfunction is indicated by reduced deceleration time and increased late filling velocity compared to in wild-type mice

growth/size/body

cardiac hypertrophy ( J:169969 )

heart left ventricle hypertrophy ( J:169969 )

Genotype
MGI:4946086

ht2

• Allelic Composition: Ttn^tm2.1Mgot/Ttn⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

muscle

abnormal muscle physiology ( J:169969 )

• mice exhibit an intermediate increase in diastolic wall stress compared with wild-type mice and homozygotes