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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agtr1atm1Uky
targeted mutation 1, Katherine Adams
MGI:4946096
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tek-cre)12Flv/0 		involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6N MGI:4946112
cn2
 		Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tagln-cre)1Her/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL MGI:4946109
cn3
 		Agtr1atm1Uky/Agtr1atm1Uky
Tg(Tagln-cre)1Her/0 		involves: C57BL/6 * C57BL/6N * SJL MGI:4946108


Genotype
MGI:4946112
cn1
Allelic
Composition		 Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Uky mutation (1 available); any Agtr1a mutation (40 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta elastic fiber morphology ( J:170230 )
• angiotensin II-treated mice fed a high-fat diet exhibit decreased elastin breaks compared with similarly treated Ldlrtm1Her homozygotes
decreased aorta wall thickness ( J:170230 )
• angiotensin II-treated mice fed a high-fat diet exhibit decreased medial thickness compared with similarly treated Ldlrtm1Her homozygotes
abnormal ascending aorta morphology ( J:170230 )
• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta lengthening compared with similarly treated Ldlrtm1Her homozygotes
decreased susceptibility to induced aneurysm formation ( J:170230 )
• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta ulcers compared with similarly treated Ldlrtm1Her homozygotes




Genotype
MGI:4946109
cn2
Allelic
Composition		 Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Uky mutation (1 available); any Agtr1a mutation (40 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:170230 )
N
• mice fed a high-fat diet exhibit the same amount of angiotensin-induced expansion of ascending aortas and aneurysms as in similarly treated Ldlrtm1Her homozygotes




Genotype
MGI:4946108
cn3
Allelic
Composition		 Agtr1atm1Uky/Agtr1atm1Uky
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Uky mutation (1 available); any Agtr1a mutation (40 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:170230 )
N
• mice exhibit normal aortic structure




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory