Phenotypes associated with this allele

• Allele Symbol: Nrxn3^tm4.1Sud
• Allele Name: targeted mutation 4.1, Thomas C Sudhof
• Allele ID: MGI:4946102
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrxn3^tm4.1Sud/Nrxn3^tm4.1Sud	involves: 129S1/Sv * 129X1/SvJ	MGI:5538251
cn2	Nrxn3^tm4.1Sud/Nrxn3^tm4.1Sud	involves: 129S1/Sv * 129X1/SvJ	MGI:5538252

Genotype
MGI:5538251

hm1

• Allelic Composition: Nrxn3^tm4.1Sud/Nrxn3^tm4.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synapse morphology ( J:199997 )

• internalization of the GluA1 component of AMPAR is increased about 60%

• AMPAR/NMDAR ratio is reduced

abnormal postsynaptic density morphology ( J:199997 )

• synapse density of AMPAR is unchanged but the post synaptic surface is reduced by 40-50%

reduced long-term potentiation ( J:199997 )

• regular firing (as opposed to burst-firing) neurons show a 70% reduction in long term potentiation (impaired LTP)

abnormal miniature excitatory postsynaptic currents ( J:199997 )

• decreased amplitude but no change in frequency

• a 45% reduction in AMPAR mediated EPSC

• NMDAR mediated currents are unaffected

Genotype
MGI:5538252

cn2

• Allelic Composition: Nrxn3^tm4.1Sud/Nrxn3^tm4.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

nervous system phenotype ( J:199997 )

N • adenovirus containing cre is injeted into the CA1 region of the hippocampus at 21 days and mice are analysed at 35-42 days of age

N • phenotype is normal

N • AMPAR/NMDAR ratio is normal

N • long term potentiation is normal