Phenotypes associated with this allele

• Allele Symbol: Nr1h2^tm1.1Nph
• Allele Name: targeted mutation 1.1, N P Hessvik
• Allele ID: MGI:4946260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1h2^tm1.1Nph/Nr1h2^tm1.1Nph	B6.129-Nr1h2^tm1.1Nph	MGI:4946263

Genotype
MGI:4946263

hm1

• Allelic Composition: Nr1h2^tm1.1Nph/Nr1h2^tm1.1Nph
• Genetic Background: B6.129-Nr1h2^tm1.1Nph

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cellular cholesterol metabolism ( J:169945 )

• after exposure to T0901317, myotubes fail to exhibit an increase in apoA1-dependent cholesterol efflux compared with wild-type cells

abnormal glucose homeostasis ( J:169945 )

• myotubes tend towards increased basal glucose oxidation compared with wild-type cells

• myotubes tend towards insulin responsiveness compared with wild-type cells

abnormal glycogen homeostasis ( J:169945 )

• myotubes tend towards increased basal glycogen synthesis compared with wild-type cells

abnormal lipid homeostasis ( J:169945 )

• after exposure to T0901317, myotubes fail to exhibit an increase in de novo lipogenesis compared with wild-type cells

abnormal cholesterol homeostasis ( J:169945 )

• myotubes exhibit increased cholesteryl esters compared with wild-type cells

cellular

abnormal cellular cholesterol metabolism ( J:169945 )

• after exposure to T0901317, myotubes fail to exhibit an increase in apoA1-dependent cholesterol efflux compared with wild-type cells

increased muscle cell glucose uptake ( J:169945 )

• myotubes exhibit increased basal glucose uptake compared with wild-type cells

• the ratio of insulin-stimulated to basal glucose uptake is lower than in wild-type cells

muscle

increased muscle cell glucose uptake ( J:169945 )

• myotubes exhibit increased basal glucose uptake compared with wild-type cells

• the ratio of insulin-stimulated to basal glucose uptake is lower than in wild-type cells