Phenotypes associated with this allele

• Allele Symbol: Trp53^tm8Xu
• Allele Name: targeted mutation 8, Yang Xu
• Allele ID: MGI:4946291
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm8Xu/Trp53^tm8Xu	Not Specified	MGI:4946294
ht2	Trp53^tm1Brd/Trp53^tm8Xu	involves: 129S7/SvEvBrd	MGI:4946295
cx3	Bbc3^tm1Gpz/Bbc3^tm1Gpz Trp53^tm1Brd/Trp53^tm8Xu	involves: 129P2/OlaHsd * 129S7/SvEvBrd	MGI:4946296

Genotype
MGI:4946294

hm1

• Allelic Composition: Trp53^tm8Xu/Trp53^tm8Xu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:170216 )

• no mice are produced

Genotype
MGI:4946295

ht2

• Allelic Composition: Trp53^tm1Brd/Trp53^tm8Xu
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

premature death ( J:170216 )

• by 6 weeks of age

premature aging ( J:170216 )

• mice exhibit aging-related phenotypes including acute spine curvature, bone marrow hypoplasia, lymphopenia, and anemia unlike wild-type mice

reproductive system

abnormal male germ cell apoptosis ( J:170216 )

♂

small testis ( J:170216 )

♂ • progressive

abnormal spermatogenesis ( J:170216 )

♂ • the number of spermatogonial stem cells is depleted compared to in wild-type mice

hematopoietic system

anemia ( J:170216 )

• progressive

decreased bone marrow cell number ( J:170216 )

decreased leukocyte cell number ( J:170216 )

• by 2 weeks of age

decreased hematopoietic stem cell number ( J:170216 )

• in the fetal liver and bone marrow

growth/size/body

decreased body size ( J:170216 )

• by 2 weeks of age

decreased body weight ( J:170216 )

• by 4 weeks of age

nervous system

decreased neuronal precursor cell number ( J:170216 )

skeleton

abnormal spine curvature ( J:170216 )

digestive/alimentary system

increased enterocyte apoptosis ( J:170216 )

endocrine/exocrine glands

small testis ( J:170216 )

♂ • progressive

immune system

decreased leukocyte cell number ( J:170216 )

• by 2 weeks of age

cellular

increased enterocyte apoptosis ( J:170216 )

abnormal male germ cell apoptosis ( J:170216 )

♂

Genotype
MGI:4946296

cx3

• Allelic Composition: Bbc3^tm1Gpz/Bbc3^tm1Gpz; Trp53^tm1Brd/Trp53^tm8Xu
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

mortality/aging

mortality/aging ( J:170216 )

N • the segmental progeria phenotypes observed in Trp53^tm1Brd/Trp53^tm8Xu mice are rescued

N • mice survive longer than Trp53^tm1Brd/Trp53^tm8Xu mice

reproductive system

reproductive system phenotype ( J:170216 )

N • testes atrophy observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

N • depletion of adult stem cells in the testes observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

immune system

decreased thymocyte number ( J:170216 )

• not as severe as in Trp53^tm1Brd/Trp53^tm8Xu mice

nervous system

nervous system phenotype ( J:170216 )

N • depletion of adult stem cells in the brain observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

digestive/alimentary system

digestive/alimentary phenotype ( J:170216 )

N • apoptosis in the crypt of small intestine observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

hematopoietic system

hematopoietic system phenotype ( J:170216 )

N • depletion of adult stem cells in the bone marrow observed in Trp53^tm1Brd/Trp53^tm8Xu mice is rescued

decreased thymocyte number ( J:170216 )

• not as severe as in Trp53^tm1Brd/Trp53^tm8Xu mice

endocrine/exocrine glands

decreased thymocyte number ( J:170216 )

• not as severe as in Trp53^tm1Brd/Trp53^tm8Xu mice