Allele Symbol Allele Name Allele ID |
Trp53tm8Xu targeted mutation 8, Yang Xu MGI:4946291 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• by 6 weeks of age
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• mice exhibit aging-related phenotypes including acute spine curvature, bone marrow hypoplasia, lymphopenia, and anemia unlike wild-type mice
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• progressive
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• the number of spermatogonial stem cells is depleted compared to in wild-type mice
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• by 2 weeks of age
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• in the fetal liver and bone marrow
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• by 2 weeks of age
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• by 4 weeks of age
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• progressive
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• by 2 weeks of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• the segmental progeria phenotypes observed in Trp53tm1Brd/Trp53tm8Xu mice are rescued
• mice survive longer than Trp53tm1Brd/Trp53tm8Xu mice
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N |
• testes atrophy observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
• depletion of adult stem cells in the testes observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
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• not as severe as in Trp53tm1Brd/Trp53tm8Xu mice
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N |
• depletion of adult stem cells in the brain observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
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N |
• apoptosis in the crypt of small intestine observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
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N |
• depletion of adult stem cells in the bone marrow observed in Trp53tm1Brd/Trp53tm8Xu mice is rescued
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• not as severe as in Trp53tm1Brd/Trp53tm8Xu mice
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• not as severe as in Trp53tm1Brd/Trp53tm8Xu mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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