Phenotypes associated with this allele

• Allele Symbol: Pld6^tm1.1Mafr
• Allele Name: targeted mutation 1.1, Michael A Frohman
• Allele ID: MGI:4946513
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pld6^tm1.1Mafr/Pld6^tm1.1Mafr	involves: C57BL/6	MGI:4946514

Genotype
MGI:4946514

hm1

• Allelic Composition: Pld6^tm1.1Mafr/Pld6^tm1.1Mafr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatocyte morphology ( J:169933 )

♂ • absence of aggregated mitochondria and associated nuage (intermitochondrial cement)

arrest of male meiosis ( J:169933 )

♂ • absence of late meiotic and post meiotic spermatocytes

abnormal seminiferous tubule morphology ( J:169933 )

♂ • tubules contain many apoptotic cells, cells containing disorganized chromosomal material, vacuoles suggestive of cell dropouts and cell debris sloughed into the lumen of the tubules

abnormal male reproductive system physiology ( J:169933 )

♂ • analysis indicates substantial genomic damage in spermatocytes

male infertility ( J:169933 )

♂ • all males are infertile

cellular

abnormal spermatocyte morphology ( J:169933 )

♂ • absence of aggregated mitochondria and associated nuage (intermitochondrial cement)

abnormal mitochondrial morphology ( J:169933 )

• MEFs display shortened mitochondria

• in about 50% of MEFs mitochondrial fragments are prominent in the cellular periphery

arrest of male meiosis ( J:169933 )

♂ • absence of late meiotic and post meiotic spermatocytes

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:169933 )

♂ • tubules contain many apoptotic cells, cells containing disorganized chromosomal material, vacuoles suggestive of cell dropouts and cell debris sloughed into the lumen of the tubules