Phenotypes associated with this allele

• Allele Symbol: Slc6a4^tm1.1Rbl
• Allele Name: targeted mutation 1.1, Randy D Blakely
• Allele ID: MGI:4946603
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a4^tm1.1Rbl/Slc6a4^tm1.1Rbl	129S6/SvEvTac-Slc6a4^tm1.1Rbl	MGI:4946606

Genotype
MGI:4946606

hm1

• Allelic Composition: Slc6a4^tm1.1Rbl/Slc6a4^tm1.1Rbl
• Genetic Background: 129S6/SvEvTac-Slc6a4^tm1.1Rbl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:170356 )

• mice exhibit reduced sensitivity to serotonin antagonists (fluoxetine, cocaine, citalopram, and escitalopram) compared with wild-type mice

• serotonergic neurons exhibit diminished inhibition mediated by selective serotonin re-uptake inhibitors (SSRI) compared with wild-type neurons

behavior/neurological

impaired behavioral response to xenobiotic ( J:170356 )

• mice treated with citalopram, fluoxetine, or paroxetine exhibit reduced impact on behavior in a tail suspension test and forced swim test compared with wild-type mice

nervous system

abnormal neuron physiology ( J:170356 )

• serotonergic neurons exhibit diminished inhibition mediated by selective serotonin re-uptake inhibitors (SSRI) compared with wild-type neurons