Phenotypes associated with this allele

• Allele Symbol: Slc5a2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:4946611
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc5a2^tm1Lex/Slc5a2^tm1Lex	B6.129S5-Slc5a2^tm1Lex	MGI:4946613
hm2	Slc5a2^tm1Lex/Slc5a2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5487582
cx3	Slc5a1^Gt(OST315271)Lex/Slc5a1^Gt(OST315271)Lex Slc5a2^tm1Lex/Slc5a2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5487583

Genotype
MGI:4946613

hm1

• Allelic Composition: Slc5a2^tm1Lex/Slc5a2^tm1Lex
• Genetic Background: B6.129S5-Slc5a2^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal glucose reabsorption ( J:169917 )

• absolute and fractional renal reabsorption of glucose is lower than in wild-type mice

• resorbption of glucose in the early proximal tubule is normal compared to in wild-type mice

increased urine glucose level ( J:169917 )

decreased urine osmolality ( J:169917 )

abnormal renal filtration rate ( J:169917 )

• glucose renal clearance is increased compared to in wild-type mice

polyuria ( J:169917 )

homeostasis/metabolism

decreased circulating aldosterone level ( J:169917 )

abnormal renal glucose reabsorption ( J:169917 )

• absolute and fractional renal reabsorption of glucose is lower than in wild-type mice

• resorbption of glucose in the early proximal tubule is normal compared to in wild-type mice

increased urine glucose level ( J:169917 )

decreased urine osmolality ( J:169917 )

increased renin activity ( J:169917 )

behavior/neurological

increased fluid intake ( J:169917 )

increased food intake ( J:169917 )

Genotype
MGI:5487582

hm2

• Allelic Composition: Slc5a2^tm1Lex/Slc5a2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

homeostasis/metabolism

abnormal blood homeostasis ( J:195941 )

abnormal circulating glucose level ( J:195941 )

• mice treated with streptozotocin exhibit a slight increase in blood glucose compared with a larger increase observed in wild-type mice

decreased circulating glucose level ( J:195941 )

• in streptozotocin-treated mice

decreased circulating insulin level ( J:195941 )

• after glucose challenge whether fed standard chow or a high fat diet

decreased circulating phosphate level ( J:195941 )

• phosphorus in streptozotocin-treated mice

increased circulating sodium level ( J:195941 )

• in streptozotocin-treated mice

improved glucose tolerance ( J:195941 )

• whether fed standard chow or a high fat diet

• in mice treated with streptozotocin

increased circulating chloride level ( J:195941 )

• in streptozotocin-treated mice

abnormal urine homeostasis ( J:195941 )

increased urine creatinine level ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

increased urine potassium level ( J:195941 )

increased urine sodium level ( J:195941 )

increased urine magnesium level ( J:195941 )

increased urine phosphate level ( J:195941 )

• phosphorus

increased urine urea nitrogen level ( J:195941 )

adipose tissue

adipose tissue phenotype ( J:195941 )

N • mice fed a high fat exhibit normal body fat

decreased total body fat amount ( J:195941 )

• in pair-fed, but not ad libitum-fed, mice

behavior/neurological

behavior/neurological phenotype ( J:195941 )

N • mice fed a high fat exhibit normal food consumption

N • mice exhibit normal locomotor activity

increased food intake ( J:195941 )

• in vehicle-treated mice

growth/size/body

growth/size/body region phenotype ( J:195941 )

N • mice fed a high fat exhibit normal body weight

decreased body weight ( J:195941 )

• in pair-fed, but not ad libitum-fed, mice

skeleton

increased bone mineral density ( J:195941 )

♀ • in the spine of female, but not male, mice at 53 weeks

increased bone trabecula number ( J:195941 )

♀ • in the fifth lumbar vertebra spine of female, but not male, mice at 53 weeks

immune system

decreased susceptibility to autoimmune diabetes ( J:195941 )

• in mice treated with streptozotocin

renal/urinary system

abnormal urine homeostasis ( J:195941 )

increased urine creatinine level ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

increased urine potassium level ( J:195941 )

increased urine sodium level ( J:195941 )

increased urine magnesium level ( J:195941 )

increased urine phosphate level ( J:195941 )

• phosphorus

increased urine urea nitrogen level ( J:195941 )

abnormal bladder urine volume ( J:195941 )

• whether treated with streptozotocin or vehicle, mice exhibit increased urine volume compared with wild-type mice

• in untreated male, but not female, mice

Genotype
MGI:5487583

cx3

• Allelic Composition: Slc5a1^{Gt(OST315271)Lex}/Slc5a1^{Gt(OST315271)Lex}; Slc5a2^tm1Lex/Slc5a2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

homeostasis/metabolism

decreased circulating glucose level ( J:195941 )

• during an intraperitoneal glucose tolerance test in fasted mice fed a glucose-free high fat diet

• during a glomerular filtration study most of the 10 h interval of the light cycle in fed mice on a glucose-free high fat diet

decreased circulating insulin level ( J:195941 )

• during an intraperitoneal glucose tolerance test in fasted mice fed a glucose-free high fat diet

improved glucose tolerance ( J:195941 )

• during an intraperitoneal glucose tolerance test in mice fed a glucose-free high fat diet

abnormal urine homeostasis ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

♂ • in male, but not female, mice

increased urine potassium level ( J:195941 )

♂ • in male, but not female, mice

increased urine sodium level ( J:195941 )

• in male, but not female, mice

increased urine magnesium level ( J:195941 )

increased urine urea nitrogen level ( J:195941 )

♂

renal/urinary system

abnormal urine homeostasis ( J:195941 )

increased urine glucose level ( J:195941 )

• increased urinary glucose excretion in mice fed a glucose-free high fat diet

increased urine chloride ion level ( J:195941 )

♂ • in male, but not female, mice

increased urine potassium level ( J:195941 )

♂ • in male, but not female, mice

increased urine sodium level ( J:195941 )

• in male, but not female, mice

increased urine magnesium level ( J:195941 )

increased urine urea nitrogen level ( J:195941 )

♂

abnormal bladder urine volume ( J:195941 )

• mice exhibit increased urine volume compared with wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:195941 )

N • mice exhibit normal locomotor activity

increased food intake ( J:195941 )

♂ • in male, but not female, mice

growth/size/body

decreased body weight ( J:195941 )

♂ • in male, but not female, mice

adipose tissue

decreased total body fat amount ( J:195941 )

♂ • in male, but not female, mice