reproductive system
N |
• female mice are fertile
|
• fewer round spermatids are observed compared to in wild-type mice
|
• pachytene spermatocytes exhibit underdevelopped inter-mitochondrial cements and chromatoid bodies compared with wild-type mice
|
• at stages XII and I-III seminiferous tubules
|
• thin
|
small testis
(
J:170319
)
• as early as 4 weeks of age
|
• as early as 4 weeks of age
|
• no elongating spermatids are present in the seminiferous tubules unlike in wild-type mice
|
• mice exhibit occasional failure of meiotic prophase unlike in wild-type mice
|
• male mice are infertile
• however, round spermatids are capable of producing fertile offspring when injected into oocytes
|
cellular
• fewer round spermatids are observed compared to in wild-type mice
|
• pachytene spermatocytes exhibit underdevelopped inter-mitochondrial cements and chromatoid bodies compared with wild-type mice
|
• expression of LINE retrotransposons is derepressed in male germ cells unlike in wild-type cells
|
• mice exhibit occasional failure of meiotic prophase unlike in wild-type mice
|
• at stages XII and I-III seminiferous tubules
|
endocrine/exocrine glands
• thin
|
small testis
(
J:170319
)
• as early as 4 weeks of age
|
• as early as 4 weeks of age
|