All Phenotypes Tcf7l2<tm1.1(EGFP/cre)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcf7l2^{tm1.1(EGFP/cre)Mrc}
targeted mutation 1.1, Mario R Capecchi
MGI:4946909

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^{tm1.1(EGFP/cre)Mrc}	involves: 129S1/Sv * 129X1/SvJ	MGI:4946923
cn2	Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.1Mrc	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl	MGI:4946928
cn3	Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.2Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:4946929
cx4	Apc^Min/Apc⁺ Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4946925

Allelic Composition	Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^{tm1.1(EGFP/cre)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^{tm1.1(EGFP/cre)Mrc} mutation (1 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:170088 )

• mice are not viable at birth

digestive/alimentary system

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

abnormal intestine morphology ( J:170088 )

• the intestines are fragile compared to in wild-type mice

• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice

abnormal intestinal enteroendocrine cell morphology ( J:170088 )

• absent in the small intestine

• elongated with large abnormally shaped nuclei in the colon

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

abnormal colon morphology ( J:170088 )

• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

abnormal colon goblet cell morphology ( J:170088 )

• incorrectly localized in the colon

abnormal small intestine morphology ( J:170088 )

abnormal small intestine goblet cell morphology ( J:170088 )

• absent in the small intestine

cellular

abnormal colon goblet cell morphology ( J:170088 )

• incorrectly localized in the colon

abnormal small intestine goblet cell morphology ( J:170088 )

• absent in the small intestine

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:170088 )

behavior/neurological

absent gastric milk in neonates ( J:170088 )

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

abnormal colon goblet cell morphology ( J:170088 )

• incorrectly localized in the colon

embryo

embryo tissue necrosis ( J:170088 )

• throughout the intestine by E16.5

Allelic Composition	Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.1Mrc
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^{tm1.1(EGFP/cre)Mrc} mutation (1 available); any Tcf7l2 mutation (58 available)
Tcf7l2^tm2.1Mrc mutation (1 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:170088 )

• mice are not viable at birth

digestive/alimentary system

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

abnormal intestine morphology ( J:170088 )

• the intestines are fragile compared to in wild-type mice

• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal intestinal enteroendocrine cell morphology ( J:170088 )

• absent in the small intestine

• elongated with large abnormally shaped nuclei in the colon

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

abnormal colon morphology ( J:170088 )

• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

abnormal small intestine morphology ( J:170088 )

cellular

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:170088 )

behavior/neurological

absent gastric milk in neonates ( J:170088 )

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

embryo

embryo tissue necrosis ( J:170088 )

• throughout the intestine by E16.5

Allelic Composition	Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.2Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^{tm1.1(EGFP/cre)Mrc} mutation (1 available); any Tcf7l2 mutation (58 available)
Tcf7l2^tm2.2Mrc mutation (0 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:170088 )

• mice are not viable at birth

digestive/alimentary system

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

abnormal intestine morphology ( J:170088 )

• the intestines are fragile compared to in wild-type mice

• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal intestinal enteroendocrine cell morphology ( J:170088 )

• absent in the small intestine

• elongated with large abnormally shaped nuclei in the colon

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

abnormal colon morphology ( J:170088 )

• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

abnormal small intestine morphology ( J:170088 )

cellular

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:170088 )

behavior/neurological

absent gastric milk in neonates ( J:170088 )

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

embryo

embryo tissue necrosis ( J:170088 )

• throughout the intestine by E16.5

Allelic Composition	Apc^Min/Apc⁺ Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Tcf7l2^{tm1.1(EGFP/cre)Mrc} mutation (1 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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