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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tcf7l2tm2.2Mrc
targeted mutation 2.2, Mario R Capecchi
MGI:4946911
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc involves: 129S1/Sv MGI:4946930
cn2
Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc involves: 129S1/Sv * 129X1/SvJ MGI:4946929
cx3
ApcMin/Apc+
Tcf7l2tm2.2Mrc/Tcf7l2+
involves: C57BL/6J MGI:4946927


Genotype
MGI:4946930
hm1
Allelic
Composition
Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2tm2.2Mrc mutation (0 available); any Tcf7l2 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are not viable at birth

digestive/alimentary system
• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice
• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice
• the number of proliferating cells in the colon is decreased compared to in wild-type mice
• the intestines are fragile compared to in wild-type mice
• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice
• absent in the small intestine
• incorrectly localized in the colon
• absent in the small intestine
• elongated with large abnormally shaped nuclei in the colon
• mice lack crypt structures due to necrosis unlike wild-type mice
• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

cellular
• incorrectly localized in the colon
• absent in the small intestine
• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice
• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice
• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

behavior/neurological

endocrine/exocrine glands
• mice lack crypt structures due to necrosis unlike wild-type mice

embryo
• throughout the intestine by E16.5




Genotype
MGI:4946929
cn2
Allelic
Composition
Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2tm1.1(EGFP/cre)Mrc mutation (1 available); any Tcf7l2 mutation (58 available)
Tcf7l2tm2.2Mrc mutation (0 available); any Tcf7l2 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are not viable at birth

digestive/alimentary system
• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice
• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice
• the number of proliferating cells in the colon is decreased compared to in wild-type mice
• the intestines are fragile compared to in wild-type mice
• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice
• absent in the small intestine
• incorrectly localized in the colon
• absent in the small intestine
• elongated with large abnormally shaped nuclei in the colon
• mice lack crypt structures due to necrosis unlike wild-type mice
• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

cellular
• absent in the small intestine
• incorrectly localized in the colon
• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice
• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice
• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

behavior/neurological

endocrine/exocrine glands
• mice lack crypt structures due to necrosis unlike wild-type mice

embryo
• throughout the intestine by E16.5




Genotype
MGI:4946927
cx3
Allelic
Composition
ApcMin/Apc+
Tcf7l2tm2.2Mrc/Tcf7l2+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Tcf7l2tm2.2Mrc mutation (0 available); any Tcf7l2 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop colorectal tubular adenomas unlike Apcmin heterozygotes

digestive/alimentary system
• mice develop colorectal tubular adenomas unlike Apcmin heterozygotes





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory