Phenotypes associated with this allele

• Allele Symbol: Tcf7l2^tm2.2Mrc
• Allele Name: targeted mutation 2.2, Mario R Capecchi
• Allele ID: MGI:4946911
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf7l2^tm2.2Mrc/Tcf7l2^tm2.2Mrc	involves: 129S1/Sv	MGI:4946930
cn2	Tcf7l2^tm1.1(EGFP/cre)Mrc/Tcf7l2^tm2.2Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:4946929
cx3	Apc^Min/Apc^+ Tcf7l2^tm2.2Mrc/Tcf7l2^+	involves: C57BL/6J	MGI:4946927

Genotype
MGI:4946930

hm1

• Allelic Composition: Tcf7l2^tm2.2Mrc/Tcf7l2^tm2.2Mrc
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:170088 )

• mice are not viable at birth

digestive/alimentary system

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

abnormal intestine morphology ( J:170088 )

• the intestines are fragile compared to in wild-type mice

• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal intestinal enteroendocrine cell morphology ( J:170088 )

• absent in the small intestine

• elongated with large abnormally shaped nuclei in the colon

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

abnormal colon morphology ( J:170088 )

• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

abnormal small intestine morphology ( J:170088 )

cellular

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:170088 )

behavior/neurological

absent gastric milk in neonates ( J:170088 )

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

embryo

embryo tissue necrosis ( J:170088 )

• throughout the intestine by E16.5

Genotype
MGI:4946929

cn2

• Allelic Composition: Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2^tm2.2Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

neonatal lethality, complete penetrance ( J:170088 )

• mice are not viable at birth

digestive/alimentary system

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

abnormal intestine morphology ( J:170088 )

• the intestines are fragile compared to in wild-type mice

• small intestine and colons exhibit decreased epithelial cells due to necrosis compared with wild-type mice

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal intestinal enteroendocrine cell morphology ( J:170088 )

• absent in the small intestine

• elongated with large abnormally shaped nuclei in the colon

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

abnormal colon morphology ( J:170088 )

• the colon is fragile and the meconium is diffuse throughout the colon compared to in wild-type mice

abnormal small intestine morphology ( J:170088 )

cellular

abnormal intestinal goblet cell morphology ( J:170088 )

• absent in the small intestine

• incorrectly localized in the colon

abnormal enterocyte proliferation ( J:170088 )

• at E13.5, mice exhibit increased proliferating cells in the intestine compared with wild-type mice

• by E16.5, no proliferation cells are found in the small intestine unlike in wild-type mice

• the number of proliferating cells in the colon is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:170088 )

behavior/neurological

absent gastric milk in neonates ( J:170088 )

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:170088 )

• mice lack crypt structures due to necrosis unlike wild-type mice

embryo

embryo tissue necrosis ( J:170088 )

• throughout the intestine by E16.5

Genotype
MGI:4946927

cx3

• Allelic Composition: Apc^Min/Apc⁺; Tcf7l2^tm2.2Mrc/Tcf7l2⁺
• Genetic Background: involves: C57BL/6J

neoplasm

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes