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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pld6tm1.1Hsas
targeted mutation 1.1, Hiroyuki Sasaki
MGI:4946932
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pld6tm1.1Hsas/Pld6tm1.1Hsas involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4946933


Genotype
MGI:4946933
hm1
Allelic
Composition		 Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld6tm1.1Hsas mutation (1 available); any Pld6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell morphology ( J:169934 )
• mitochondria are mislocalized around the centrosome adjacent to the nucleus in prospermatogonia
• electron dense pi bodies are absent from prospermatogonia
azoospermia ( J:169934 )
• absent from the epididymis at 7 weeks of age
abnormal spermatid morphology ( J:169934 )
• absent at 7 weeks of age
abnormal spermatocyte morphology ( J:169934 )
• atypical spermatocytes with either condensed or swollen nuclei appear at P16
arrest of male meiosis ( J:169934 )
• arrests between the zygotene and pachytene stages
abnormal male germ cell apoptosis ( J:169934 )
• apoptotic spermatocytes are detected in the tubules
abnormal DNA methylation during gametogenesis ( J:169934 )
• hypomethylation of 5' repeats of A type and Gf type L1 retrotransposons and of the IAP1 sequence on chromosome 3
abnormal testis physiology ( J:169934 )
• expression analysis indicates severely impaired Piwi interacting RNA primary biogenesis

endocrine/exocrine glands
abnormal testis physiology ( J:169934 )
• expression analysis indicates severely impaired Piwi interacting RNA primary biogenesis

cellular
abnormal male germ cell morphology ( J:169934 )
• mitochondria are mislocalized around the centrosome adjacent to the nucleus in prospermatogonia
• electron dense pi bodies are absent from prospermatogonia
azoospermia ( J:169934 )
• absent from the epididymis at 7 weeks of age
abnormal spermatid morphology ( J:169934 )
• absent at 7 weeks of age
abnormal spermatocyte morphology ( J:169934 )
• atypical spermatocytes with either condensed or swollen nuclei appear at P16
arrest of male meiosis ( J:169934 )
• arrests between the zygotene and pachytene stages
abnormal male germ cell apoptosis ( J:169934 )
• apoptotic spermatocytes are detected in the tubules
abnormal DNA methylation during gametogenesis ( J:169934 )
• hypomethylation of 5' repeats of A type and Gf type L1 retrotransposons and of the IAP1 sequence on chromosome 3




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory