Phenotypes associated with this allele

• Allele Symbol: Calr3^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:4946941
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calr3^tm1Osb/Calr3^tm1Osb	involves: 129S2/SvPas * C57BL/6	MGI:4946943

Genotype
MGI:4946943

hm1

• Allelic Composition: Calr3^tm1Osb/Calr3^tm1Osb
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired sperm migration in female genital tract ( J:170595 )

♂ • sperm exhibit impaired migration into the oviduct compared with wild-type sperm

♂ • however, sperm motility is normal

reproductive system

reproductive system phenotype ( J:170595 )

♀N • female mice are fertile

impaired sperm migration in female genital tract ( J:170595 )

♂ • sperm exhibit impaired migration into the oviduct compared with wild-type sperm

♂ • however, sperm motility is normal

male infertility ( J:170595 )

♂ • however, transgenic expression recovers male fertility

♂ • male mice are infertile

impaired fertilization ( J:170595 )

♂ • sperm exhibit reduced in vitro fertilization compared with wild-type sperm

impaired binding of sperm to zona pellucida ( J:170595 )

♂ • sperm fail to bind to the zona pellucida compared with wild-type sperm