Phenotypes associated with this allele

• Allele Symbol: Tg(NEFH)398Jpj
• Allele Name: transgene insertion 398, Jean-Pierre Julien
• Allele ID: MGI:4947051
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(NEFH)398Jpj/0 Tg(SOD1*G37R)29Dpr/0	involves: C3H/HeJ * C57BL/6 * C57BL/6J	MGI:4947061
tg2	Tg(NEFH)398Jpj/0	involves: C57BL/6	MGI:4947060

Genotype
MGI:4947061

cx1

• Allelic Composition: Tg(NEFH)398Jpj/0; Tg(SOD1*G37R)29Dpr/0
• Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:69179 )

• extended mean longevity by about 2 months, compared with Tg(SOD1*G37R)29Dpr/0 mice

nervous system

motor neuron degeneration ( J:69179 )

• less axonal loss and cell death in the motor axons in one-year old mice, compared with Tg(SOD1*G37R)29Dpr/0 mice

decreased sensory neuron number ( J:69179 )

• less axonal loss and cell death in the sensory axons in one-year old mice, compared with Tg(SOD1*G37R)29Dpr/0 mice

Genotype
MGI:4947060

tg2

• Allelic Composition: Tg(NEFH)398Jpj/0
• Genetic Background: involves: C57BL/6

nervous system

abnormal motor neuron morphology ( J:69179 )

• neurofilament accumulations in lower motor neurons

motor neuron degeneration ( J:69179 )

• atrophy and slow degeneration of motor axons in old transgenic mice

behavior/neurological

limb grasping ( J:69179 )

• limb contraction reflexes during aging

tremors ( J:69179 )

• fine tremors during aging