Phenotypes associated with this allele

• Allele Symbol: Enpp7^tm1Rudd
• Allele Name: targeted mutation 1, Rui-Don Duan
• Allele ID: MGI:4947121
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Enpp7^tm1Rudd/Enpp7^tm1Rudd	involves: 129S1/Sv * C57BL/6	MGI:4947122

Genotype
MGI:4947122

hm1

• Allelic Composition: Enpp7^tm1Rudd/Enpp7^tm1Rudd
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal feces composition ( J:170667 )

• feces content of sphingomyelin is increased while ceramide is decreased compared to in wild-type mice

abnormal intestinal epithelium morphology ( J:170667 )

• mice exhibit hypertrophy of the intestinal epithelium unlike wild-type mice

abnormal intestinal mucosa morphology ( J:170667 )

• the muscular layer beneath the crypts is decreased compared to in wild-type mice

abnormal small intestine crypts of Lieberkuhn morphology ( J:170667 )

• decreased width

decreased small intestinal villus size ( J:170667 )

• decreased width

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:170667 )

• alkaline phosphatase activity in the mucosa of the small intestine is decreased compared to in wild-type mice

neoplasm

neoplasm ( J:170667 )

N • mice do not develop tumors in the intestine

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:170667 )

• decreased width