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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Derl2tm1.1Hpl
targeted mutation 1.1, Hidde Ploegh
MGI:4947125
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Derl2tm1.1Hpl/Derl2tm1.1Hpl 		involves: 129P2/OlaHsd MGI:4947223
cn2
 		Derl2tm1.1Hpl/Derl2tm1.1Hpl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA MGI:4947224


Genotype
MGI:4947223
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Derl2tm1.1Hpl/Derl2tm1.1Hpl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Derl2tm1.1Hpl mutation (0 available); any Derl2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:170650 )
N
• B cell development and antibody secretion are normal




Genotype
MGI:4947224
cn2
Allelic
Composition		 Derl2tm1.1Hpl/Derl2tm1.1Hpl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Derl2tm1.1Hpl mutation (0 available); any Derl2 mutation (18 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:170650 )
N
• liver function is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory