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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhotm1.1Kpal
targeted mutation 1.1, Krzysztof Palczewski
MGI:4947230
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhotm1.1Kpal/Rhotm1.1Kpal involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947237
ht2
 		Rhotm1.1Kpal/Rho+ involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947235
cx3
 		Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947236


Genotype
MGI:4947237
hm1
Allelic
Composition		 Rhotm1.1Kpal/Rhotm1.1Kpal
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation (1 available); any Rho mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice

vision/eye
decreased retina photoreceptor cell number ( J:170648 )
• at P63, photoreceptor cells are almost gone unlike in wild-type mice

nervous system
decreased retina photoreceptor cell number ( J:170648 )
• at P63, photoreceptor cells are almost gone unlike in wild-type mice




Genotype
MGI:4947235
ht2
Allelic
Composition		 Rhotm1.1Kpal/Rho+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation (1 available); any Rho mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice

vision/eye
abnormal retina layer morphology ( J:170648 )
• the distance between retina pigmented epithelium and the outer limiting membrane is reduced compared to in wild-type mice
decreased retina rod cell number ( J:170648 )
• half the number in wild-type mice
short retina rod cell outer segment ( J:170648 )
• shortened at P35 and P112
retina rod cell degeneration ( J:170648 )
• due to necrosis
abnormal cone electrophysiology ( J:170648 )
• continuous decline until P276
• mildly reduced at P70
• severely depressed at P170
abnormal rod electrophysiology ( J:170648 )
• severely reduced at P41
• nearly undetectable by P170

nervous system
decreased retina rod cell number ( J:170648 )
• half the number in wild-type mice
short retina rod cell outer segment ( J:170648 )
• shortened at P35 and P112
retina rod cell degeneration ( J:170648 )
• due to necrosis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
 J:170648




Genotype
MGI:4947236
cx3
Allelic
Composition		 Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrattm1Kpal mutation (1 available); any Lrat mutation (26 available)
Rhotm1.1Kpal mutation (1 available); any Rho mutation (51 available)
Rpe65450L mutation (1 available); any Rpe65 mutation (52 available)
Rpe65450M mutation (2 available); any Rpe65 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Effect of genetic depletion of 11-cis-retinal production (Lrattm1Kpal/Lrattm1Kpal) on retinal degeneration in Rhotm1.1Kpal/Rho+ mice

vision/eye
decreased retina photoreceptor cell number ( J:170648 )
• dramatically reduced at P36
abnormal retina rod cell outer segment morphology ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes
retina photoreceptor degeneration ( J:170648 )
• due to increased apoptosis
retina rod cell degeneration ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes

nervous system
decreased retina photoreceptor cell number ( J:170648 )
• dramatically reduced at P36
abnormal retina rod cell outer segment morphology ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes
retina photoreceptor degeneration ( J:170648 )
• due to increased apoptosis
retina rod cell degeneration ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory