Phenotypes associated with this allele

• Allele Symbol: Ptpn6^me-B2
• Allele Name: motheaten B2
• Allele ID: MGI:4947257
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn6^me-B2/Ptpn6^me-B2	involves: BALB/c	MGI:4947283

Genotype
MGI:4947283

hm1

• Allelic Composition: Ptpn6^me-B2/Ptpn6^me-B2
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169850 )

• mice die of interstitial pneumonia within a few months if not treated with antibiotics

reproductive system

reproductive system phenotype ( J:169850 )

N • male mice with late onset condition or treated with early preventative suppressive therapy are fertile

absent tertiary ovarian follicles ( J:169850 )

♀ • mice subjected to hormone-induced superovulation lack Graafian follicles unlike wild-type mice

ovary atrophy ( J:169850 )

♀

female infertility ( J:169850 )

♀

immune system

small thymus ( J:169850 )

increased neutrophil cell number ( J:169850 )

• in the paws, spleen, and lung

increased IgG level ( J:169850 )

increased IgM level ( J:169850 )

abnormal circulating chemokine level ( J:169850 )

• mice exhibit increased serum G-CSF compared with wild-type mice

increased circulating interferon-gamma level ( J:169850 )

• LPS-stimulated and Con-A stimulated mice

increased circulating interleukin-1 beta level ( J:169850 )

• in unstimulated, LPS-stimulated, and Con-A stimulated mice

increased circulating interleukin-10 level ( J:169850 )

• in unstimulated and LPS-stimulated mice

increased circulating interleukin-6 level ( J:169850 )

• in unstimulated, LPS-stimulated, and Con-A stimulated mice

increased circulating serum amyloid protein level ( J:169850 )

interstitial pneumonia ( J:169850 )

• mice die of interstitial pneumonia within a few months if not treated with antibiotics

skin inflammation ( J:169850 )

• with edema, redness, and microabscesses

• milder than in other motheaten mutants

integument

skin inflammation ( J:169850 )

• with edema, redness, and microabscesses

• milder than in other motheaten mutants

respiratory system

interstitial pneumonia ( J:169850 )

• mice die of interstitial pneumonia within a few months if not treated with antibiotics

homeostasis/metabolism

abnormal circulating chemokine level ( J:169850 )

• mice exhibit increased serum G-CSF compared with wild-type mice

increased circulating interferon-gamma level ( J:169850 )

• LPS-stimulated and Con-A stimulated mice

increased circulating interleukin-1 beta level ( J:169850 )

• in unstimulated, LPS-stimulated, and Con-A stimulated mice

increased circulating interleukin-10 level ( J:169850 )

• in unstimulated and LPS-stimulated mice

increased circulating interleukin-6 level ( J:169850 )

• in unstimulated, LPS-stimulated, and Con-A stimulated mice

increased circulating serum amyloid protein level ( J:169850 )

extremity edema ( J:169850 )

• in paws

endocrine/exocrine glands

small thymus ( J:169850 )

absent tertiary ovarian follicles ( J:169850 )

♀ • mice subjected to hormone-induced superovulation lack Graafian follicles unlike wild-type mice

ovary atrophy ( J:169850 )

♀

hematopoietic system

small thymus ( J:169850 )

increased neutrophil cell number ( J:169850 )

• in the paws, spleen, and lung

increased IgG level ( J:169850 )

increased IgM level ( J:169850 )

abnormal bone marrow cell physiology ( J:169850 )

• granulocyte precursor proliferation in the bone marrow is reduced compared to in wild-type mice