Phenotypes associated with this allele

• Allele Symbol: Dusp4^tm1Plev
• Allele Name: targeted mutation 1, Robin Plevin
• Allele ID: MGI:4947517
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp4^tm1Plev/Dusp4^tm1Plev	involves: 129/Sv * C57BL/6	MGI:4947547

Genotype
MGI:4947547

hm1

• Allelic Composition: Dusp4^tm1Plev/Dusp4^tm1Plev
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG1 level ( J:170774 )

• following shaved back rump infection with Leishmania mexicana

decreased IgG2a level ( J:170774 )

• following L. mexicana footpad infection

abnormal macrophage physiology ( J:170774 )

• bone marrow-derived macrophage exhibit impaired ability to control L. mexicana growth compared with wild-type cells

• however, ability to control L. mexicana growth is restored by treatment with IFN-gamma and LPS or L-arginine inhibition

decreased interferon-gamma secretion ( J:170774 )

• following L. mexicana footpad infection

decreased interleukin-10 secretion ( J:170774 )

• in macrophages stimulated with LPS

increased interleukin-12 secretion ( J:170774 )

• in macrophages stimulated with LPS

increased interleukin-13 secretion ( J:170774 )

• in ConA-stimulated splenocyte

increased interleukin-4 secretion ( J:170774 )

• in ConA-stimulated splenocyte

increased interleukin-6 secretion ( J:170774 )

• in macrophages stimulated with LPS

increased tumor necrosis factor secretion ( J:170774 )

• in macrophages stimulated with LPS

increased susceptibility to parasitic infection ( J:170774 )

• following foot pad infection with Leishmania mexicana, mice exhibit increased parasitic burden and reduced IgG2a and IFN-gamma production compared with wild-type mice

• following shaved back rump infection with L. mexicana, mice exhibit earlier and more rapid lesion growth and expanded Th2 response (IgG1 production) compared with wild-type mice

• bone marrow-derived macrophage exhibit impaired ability to control L. mexicana growth compared with wild-type cells

• however, ability to control L. mexicana growth is restored by treatment with IFN-gamma and LPS or L-arginine inhibition

hematopoietic system

increased IgG1 level ( J:170774 )

• following shaved back rump infection with Leishmania mexicana

decreased IgG2a level ( J:170774 )

• following L. mexicana footpad infection

abnormal macrophage physiology ( J:170774 )

• bone marrow-derived macrophage exhibit impaired ability to control L. mexicana growth compared with wild-type cells

• however, ability to control L. mexicana growth is restored by treatment with IFN-gamma and LPS or L-arginine inhibition