digestive/alimentary system
N |
• mice exhibit normal stomach pH and response to histamine
|
Allele Symbol Allele Name Allele ID |
Kcne3tm1Gwab targeted mutation 1, Geoffrey W Abbott MGI:4947550 |
||||||||||||||||||||
Summary |
4 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal stomach pH and response to histamine
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice show an increase in frequency and duration of ventricular arrhythmogenesis during reperfusion immediately following transient ischemia, with all but one (which showed atrioventricular block) showing ventricular tachycardia
• pretreatment of mutants with spironolactone diminishes the differences in reperfusion arrhythmia incidence and halves the reperfusion ventricular tachycardia duration
|
|
• 9 month old females show prolonged QT(c) interval, indicating delayed ventricular repolarization
• treatment of 9 month old females with aldosterone receptor antagonist spironolactone results in no QT(c) prolongation
|
|
• prolonged T wave in 9 month old females
|
• mice show activated lymphocyte infiltration of the adrenal glands
|
• serum aldosterone concentration is 2.3-fold higher than in wild-type mice
|
• decrease in free serum HDL
|
• increase in free and total serum LDL
|
• mice show activated lymphocyte infiltration of the adrenal glands
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• stomachs are 2-fold heavier than in wild-type mice
|
• compared with wild-type mice and Kcne2tm1Gwab homozygotes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|