Phenotypes associated with this allele

• Allele Symbol: Kcne3^tm1Gwab
• Allele Name: targeted mutation 1, Geoffrey W Abbott
• Allele ID: MGI:4947550
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcne3^tm1Gwab/Kcne3^tm1Gwab	B6.Cg-Kcne3^tm1Gwab Tyr^c-2J	MGI:4947652
hm2	Kcne3^tm1Gwab/Kcne3^tm1Gwab	involves: C57BL/6	MGI:5572818
cx3	Kcne2^tm1Gwab/Kcne2^tm1Gwab Kcne3^tm1Gwab/Kcne3^tm1Gwab	involves: 129S4/SvJae * C57BL/6J	MGI:4947654
cx4	Kcne2^tm1Gwab/Kcne2^+ Kcne3^tm1Gwab/Kcne3^tm1Gwab	involves: 129S4/SvJae * C57BL/6J	MGI:4947655

Genotype
MGI:4947652

hm1

• Allelic Composition: Kcne3^tm1Gwab/Kcne3^tm1Gwab
• Genetic Background: B6.Cg-Kcne3^tm1Gwab Tyr^c-2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:170745 )

N • mice exhibit normal stomach pH and response to histamine

Genotype
MGI:5572818

hm2

• Allelic Composition: Kcne3^tm1Gwab/Kcne3^tm1Gwab
• Genetic Background: involves: C57BL/6

cardiovascular system

abnormal cardiovascular system physiology ( J:210381 )

ventricular tachycardia ( J:210381 )

• mice show an increase in frequency and duration of ventricular arrhythmogenesis during reperfusion immediately following transient ischemia, with all but one (which showed atrioventricular block) showing ventricular tachycardia

• pretreatment of mutants with spironolactone diminishes the differences in reperfusion arrhythmia incidence and halves the reperfusion ventricular tachycardia duration

prolonged QT interval ( J:210381 )

♀ • 9 month old females show prolonged QT(c) interval, indicating delayed ventricular repolarization

♀ • treatment of 9 month old females with aldosterone receptor antagonist spironolactone results in no QT(c) prolongation

abnormal T wave ( J:210381 )

♀ • prolonged T wave in 9 month old females

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:210381 )

• mice show activated lymphocyte infiltration of the adrenal glands

homeostasis/metabolism

increased circulating aldosterone level ( J:210381 )

• serum aldosterone concentration is 2.3-fold higher than in wild-type mice

decreased circulating HDL cholesterol level ( J:210381 )

• decrease in free serum HDL

increased circulating cholesterol level ( J:210381 )

increased circulating LDL cholesterol level ( J:210381 )

• increase in free and total serum LDL

immune system

increased inflammatory response ( J:210381 )

• mice show activated lymphocyte infiltration of the adrenal glands

Genotype
MGI:4947654

cx3

• Allelic Composition: Kcne2^tm1Gwab/Kcne2^tm1Gwab; Kcne3^tm1Gwab/Kcne3^tm1Gwab
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

digestive/alimentary system

enlarged stomach ( J:170745 )

• stomachs are 2-fold heavier than in wild-type mice

gastric hypertrophy ( J:170745 )

• compared with wild-type mice and Kcne2^tm1Gwab homozygotes

achlorhydria ( J:170745 )

increased stomach pH ( J:170745 )

Genotype
MGI:4947655

cx4

• Allelic Composition: Kcne2^tm1Gwab/Kcne2⁺; Kcne3^tm1Gwab/Kcne3^tm1Gwab
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

digestive/alimentary system

enlarged stomach ( J:170745 )