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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
En1tm1(Tnf)Fpit
targeted mutation 1, F Pitossi
MGI:4947582
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit involves: C57BL/6 MGI:4947650
cn2
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit involves: C57BL/6 MGI:4947651


Genotype
MGI:4947650
hm1
Allelic
Composition
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1(Tnf)Fpit mutation (0 available); any En1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit neuroprotection against 6-OHDA injection compared with wild-type mice

nervous system
N
• dopaminergic neuron viability is normal
• mice do not exhibit inflammatory infiltration or microglia activation




Genotype
MGI:4947651
cn2
Allelic
Composition
En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1(Tnf)Fpit mutation (0 available); any En1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mice transfected with a cre-expressing adenovirus
• in mice transfected with a cre-expressing adenovirus
• mice treated with an adenovirus cre exhibit degeneration of the striatal dopaminergic terminals compared with wild-type mice
• in mice transfected with a cre-expressing adenovirus
• in mice transfected with a cre-expressing adenovirus

immune system
• mice transfected with a cre-expressing adenovirus exhibit chronic monocyte recruitment compared with wild-type mice
• in mice transfected with a cre-expressing adenovirus

hematopoietic system
• mice transfected with a cre-expressing adenovirus exhibit chronic monocyte recruitment compared with wild-type mice
• in mice transfected with a cre-expressing adenovirus





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory