Analysis Tools
normal phenotype
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• homozygotes (and heterozygotes) are viable and fertile
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Allele Symbol Allele Name Allele ID |
Lrig1tm1.1(cre/ERT2)Rjc targeted mutation 1.1, Robert J Coffey MGI:4947937 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes (and heterozygotes) are viable and fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased hair shaft
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• loss of matrix progenitors
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• loss of dermal papilla cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• with tamoxifen treatement, colon tumors are observed by day 50 following Apcfldeletion with cre induction (and stochastic loss of second Apc allele)
• by day 50 there are multiple distal colonic tumors with no proximal colon tumor burden; tumor phenotype is 100% penetrant
• largest tumors are found in distal colon, many having high grade dysplasia; highest tumor number is observed in jejunum
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• with tamoxifen treatement, colon tumors are observed by day 50 following Apcfldeletion with cre induction (and stochastic loss of second Apc allele)
• by day 50 there are multiple distal colonic tumors with no proximal colon tumor burden; tumor phenotype is 100% penetrant
• largest tumors are found in distal colon, many having high grade dysplasia; highest tumor number is observed in jejunum
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 5-6 months, nearly 90% of mice develop duodenal tumors (usually low grade adenomas)
• in one instance, a 13-month old mouse had a tumor with areas showing high grade dysplasia, and focal extension of neoplastic glands into deeper layers of the bowel wall; tumor showed intact Apc however
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• number of crypts showing Lgr5-EGFP fluorescence is doubled in absence of Lrig1 protein, compared to mice with one or two copies of Lrig1
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• at 5-6 months, nearly 90% of mice develop duodenal tumors (usually low grade adenomas)
• in one instance, a 13-month old mouse had a tumor with areas showing high grade dysplasia, and focal extension of neoplastic glands into deeper layers of the bowel wall; tumor showed intact Apc however
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• number of crypts showing Lgr5-EGFP fluorescence is doubled in absence of Lrig1 protein, compared to mice with one or two copies of Lrig1
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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