Phenotypes associated with this allele

• Allele Symbol: Orc3^tm1.1Zhua
• Allele Name: targeted mutation 1.1, Zhen Huang
• Allele ID: MGI:4947979
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Orc3^tm1.1Zhua/Orc3^tm1.1Zhua Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas	MGI:4947981

Genotype
MGI:4947981

cn1

• Allelic Composition: Orc3^tm1.1Zhua/Orc3^tm1.1Zhua; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:170581 )

N • mice exhibit normal number of Cajal-Retzius cells

N • mice exhibit normal cortical basement membrane

abnormal radial glial cell morphology ( J:170581 )

• at E14.5, mice exhibit severe disruption in the radial glial scaffold compared with wild-type mice

decreased radial glial cell number ( J:170581 )

• at E14.5, mice exhibit severe loss of radial glial cells compared with wild-type mice

decreased neuronal precursor proliferation ( J:170581 )

• at E13.5, mice exhibit reduced neural progenitor division, especially near the ventricular surface, compared with wild-type mice

cellular

abnormal radial glial cell morphology ( J:170581 )

• at E14.5, mice exhibit severe disruption in the radial glial scaffold compared with wild-type mice

decreased radial glial cell number ( J:170581 )

• at E14.5, mice exhibit severe loss of radial glial cells compared with wild-type mice

decreased neuronal precursor proliferation ( J:170581 )

• at E13.5, mice exhibit reduced neural progenitor division, especially near the ventricular surface, compared with wild-type mice