Phenotypes associated with this allele

• Allele Symbol: Trim28^tm1Fca
• Allele Name: targeted mutation 1, Florence Cammas
• Allele ID: MGI:4948085
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim28^tm1Fca/Trim28^tm1Fca	Not Specified	MGI:4948086
cn2	Trim28^tm1Fca/Trim28^tm1.1Ipc Plekha5^Tg(AMH-cre)1Flor/Plekha5^+	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4948087

Genotype
MGI:4948086

hm1

• Allelic Composition: Trim28^tm1Fca/Trim28^tm1Fca
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:170392 )

• all die between E9.5 and E10.5

embryo

abnormal embryo turning ( J:170392 )

• detected at E8.5 and E9.5

embryonic growth retardation ( J:170392 )

• markedly retarded at E8.5

• at E9.5 embryos resemble E8.5 wild-type embryos

abnormal neural tube closure ( J:170392 )

• detected at E8.5 and E9.5

cellular

abnormal cell cycle ( J:170392 )

• small but significant decrease in the number of cells in S phase and increase in the number of cells in M phase in embryos at E7.5

growth/size/body

embryonic growth retardation ( J:170392 )

• markedly retarded at E8.5

• at E9.5 embryos resemble E8.5 wild-type embryos

nervous system

abnormal neural tube closure ( J:170392 )

• detected at E8.5 and E9.5

Genotype
MGI:4948087

cn2

• Allelic Composition: Trim28^tm1Fca/Trim28^tm1.1Ipc; Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

reproductive system

reproductive system phenotype ( J:170392 )

N • testes morphology is indistinguishable from controls at 7 weeks of age