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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga8tm1.1Rdav
targeted mutation 1.1, Ronald Davis
MGI:4948106
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itga8tm1.1Rdav/Itga8tm1.1Rdav
Tg(Camk2a-cre)#Szi/0 		involves: 129S6/SvEvTac * C57BL/6J * CBA MGI:4948114


Genotype
MGI:4948114
cn1
Allelic
Composition		 Itga8tm1.1Rdav/Itga8tm1.1Rdav
Tg(Camk2a-cre)#Szi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga8tm1.1Rdav mutation (1 available); any Itga8 mutation (75 available)
Tg(Camk2a-cre)#Szi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
impaired synaptic plasticity ( J:170959 )
• N-methyl-D-aspartate receptor-dependent long term potentiation is lower than in wild-type mice
reduced long-term potentiation ( J:170959 )
• N-methyl-D-aspartate receptor-dependent long term potentiation is lower than in wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:170959 )
N
• mice exhibit normal motor learning, habituation, anxiety and hippocampal-dependent spatial learning, and memory




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory