Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:4948248
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Lex/Oprm1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6NTac	MGI:4948249

Genotype
MGI:4948249

hm1

• Allelic Composition: Oprm1^tm1Lex/Oprm1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:170718 )

• morphine-treated mice, regardless of streptozocin administration, fail to exhibit an antinociception and antihyperalgesia compared with similarly treated wild-type mice

decreased chemically-elicited antinociception ( J:170718 )

• morphine-treated mice, regardless of streptozocin administration, fail to exhibit an antinociception and antihyperalgesia compared with similarly treated wild-type mice

• tapentadol-treated mice, regardless of streptozocin administration, exhibit reduced antinociception and antihyperalgesia compared with similarly treated wild-type mice

• mice treated with tapentodal and yohimbine fail to exhibit an antinociceptive effect unlike similarly treated wild-type mice

increased thermal nociceptive threshold ( J:170718 )

• on a hot plate, streptozocin-treated mice exhibit slightly fewer nocifensive reactions compared with wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:170718 )

• fewer streptozocin-treated mice exhibit increased plasma glucose compared with similarly treated wild-type mice